While all control mice died, four of nine receiving the reticular cells survived.
The researchers found that the reticular cells trigger the release of nitric oxide using an enzyme called nitric oxide synthase-2.
The cells are pleomorphic and consist mainly of large heterogeneous reticular cells (black arrow).
Reticular cells have indistinct cell margins and abundant, finely pale eosinophilic cytoplasm, as well as amphophilic vacuoles of different sizes (black arrow).
are also localised around type L vessels in the perisinusoidal region [67, 69].
Hassall's corpuscles in the thymus are formed from degeneration of compact masses of reticular cells. It is observed that the corpuscle formation is around hypertrophied reticular cells and degenerated vessels (Kostowiecki, 1930, (13)).
Paul Kohnen (1964, (17)), in a study of thymic corpuscles in guinea pig suggested that the central core of Hassall's corpuscle consists of reticular cells with lamellation.
Other cellular targets of EBOV include hepatocytes, adrenal cortical cells, fibroblasts, fibroblastic reticular cells, stromal cells of reproductive organs, and a variety of epithelial cell types.
Most of these cell types also contained GP antigen as well, including hepatocytes; adrenal cortical cells; the epithelium of the tongue, tonsil, esophagus, and urinary bladder; ovarian thecal cells; fibroblasts of many tissues; fibroblastic reticular cells of the lymph nodes and tonsils; and the fibroblastic reticulum of the liver and adrenal cortex (Figure 1).