The mortality rate in the group treated with reteplase
had 4.5% and group treated with streptokinase had 5.2% during hospital stay.
Kirmani et al., "Intra-arterial reteplase
and intravenous abciximab in patients with acute ischemic stroke: an open-label, dose-ranging, phase I study," Neurosurgery, vol.
is a recombinant non-glycosylated form of human tPA produced in Escherichia coli (E.
Plasmids were digested with Nco, and BamH, restriction enzymes to obtain reteplase
Both alteplase and reteplase
demonstrate well-defined bell-shaped curves of fibrinolytic activity.
has been used in thrombosed hemodialysis access grafts (Falk et al., 2001; Gibbens et al., 2001) and is available in 10 U vials, which are reconstituted with 10 ml of sterile water for injection.
and alteplase (t-PA) are tissue-plasminogen activators.
But the value of adding reviparin or a similar agent remains in doubt when patients are treated with the fibrin-specific drugs typically used for thrombolysis in the United States, such as alteplase (tissue plasminogen activator), reteplase
, and tenecteplase.
BRAVE was an open-label multicenter trial involving 253 German acute MI patients randomized to half-dose reteplase
plus full-dose abciximab or to abciximab alone during the interval between diagnosis and transfer to a cardiac catheterization lab for PCI.
All of these agents are given intravenously Alteplase (Activase), reteplase
(Retavase), and tenecteplase (TNKase), produced with recombinant DNA technology are not teratogenic in animals and are all rated C.