reteplase


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Related to reteplase: Tenecteplase

reteplase

 [ret´ĕ-plās]
a recombinant form of tissue plasminogen activator; used intravenously as a thrombolytic agent in treatment of myocardial infarction.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

reteplase

(rĕ-tĕ'plāz),
A fibrinolytic agent that works by stimulating production of plasmin.
See also: plasmin.
Farlex Partner Medical Dictionary © Farlex 2012

PLAT

A gene on chromosome 8p12 that encodes tissue plasminogen activator, which converts inactive plasminogen to plasmin by hydrolysing a single Arg-Val bond in plasminogen, thereby playing a key role in tissue remodelling, degradation, cell migration and other cellular events. PLAT directly facilitates neuronal migration.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

reteplase

Retavase Cardiology A recombinant mutant of alteplase–tPA used to treat acute MI. See Acute myocardial infarction, GUSTO V.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

reteplase

A drug that dissolves blood clots. A fibrinolytic drug used in the early stages of a heart attack to try to restore patency to a coronary artery branch that has been blocked by a blood clot. A brand name is Rapilysin.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
The mortality rate in the group treated with reteplase had 4.5% and group treated with streptokinase had 5.2% during hospital stay.
Kirmani et al., "Intra-arterial reteplase and intravenous abciximab in patients with acute ischemic stroke: an open-label, dose-ranging, phase I study," Neurosurgery, vol.
Reteplase is a recombinant non-glycosylated form of human tPA produced in Escherichia coli (E.
Plasmids were digested with Nco, and BamH, restriction enzymes to obtain reteplase cDNA inserts.
Both alteplase and reteplase demonstrate well-defined bell-shaped curves of fibrinolytic activity.
Reteplase has been used in thrombosed hemodialysis access grafts (Falk et al., 2001; Gibbens et al., 2001) and is available in 10 U vials, which are reconstituted with 10 ml of sterile water for injection.
Both reteplase and alteplase (t-PA) are tissue-plasminogen activators.
But the value of adding reviparin or a similar agent remains in doubt when patients are treated with the fibrin-specific drugs typically used for thrombolysis in the United States, such as alteplase (tissue plasminogen activator), reteplase, and tenecteplase.
BRAVE was an open-label multicenter trial involving 253 German acute MI patients randomized to half-dose reteplase plus full-dose abciximab or to abciximab alone during the interval between diagnosis and transfer to a cardiac catheterization lab for PCI.
All of these agents are given intravenously Alteplase (Activase), reteplase (Retavase), and tenecteplase (TNKase), produced with recombinant DNA technology are not teratogenic in animals and are all rated C.