Recent studies have shown that laser can repair OIIRR (Altan et al.), reducing the area and volume of the resorption lacunae
generated by the application of orthodontic force (Suzuki et al., 2016).
During bone resorption, the acid pH in the resorption lacunae
increases the release of Bps from hydroxyapatite.
After staining with hematoxylin and eosin, number of osteoclasts (multinuclear cells in the resorption lacunae
close to the bone surface) were quantified under x 40 magnifications in five consecutive microscopic fields by two histopathologist.
In apical areas of Groups I and II, inflammatory alterations of the pulp were observed, such as the presence of mononuclear inflammatory cells, odontoclasts in resorption lacunae
on the inner surface (Figure 1B) and variations in the odonto-blast layer that shows disorganization.
###show superficial resorption lacunae
repaired###Normal periodontal ligament
Osteoclasts were identified as cells inside the resorption lacunae
on the bone surface.
Kasai, "Expressions of RANKL/RANK and M-CSF/c-fms in root resorption lacunae
in rat molar by heavy orthodontic force," European Journal of Orthodontics, vol.
Osteoclasts were identified as large multinucleated TRAP-positive (red coloured) cells located on the bone perimeter within a resorption lacunae
The positive control group displayed widespread root resorption lacunae
. These resorption lacunae
had clear-cut yet irregular rims (Fig.
TRAP is synthesized by the osteoclast, released into the resorption lacunae
, and presumed to help in the dissolution of the mineral matrix.
[10,11] Deposits of immunoglobulins (Ig) G, M, and A and complement C3 can be found along the resorption lacunae
and in osteocytes and chondrocytes surrounding the affected areas (table).
2A), the resorption lacunae
promoted by a lower dose of PTH (Group II) were more numerous and larger than those promoted by higher dose of PTH (Group III).