resiniferatoxin

Neurology An agent for treating urge incontinence in Pts with neurologic disease–eg, spinal cord injury and multiple sclerosis

References in periodicals archive ?

Resiniferatoxin could be administered to patients at doses and for intervals that result in maximum protection and fewest side effects.

Intraluminal Administration of Resiniferatoxin Protects against Clostridium difficile Toxin A-Induced Colitis

Chen, "Resiniferatoxin induces paradoxical changes in thermal and mechanical sensitivities in rats: mechanism of action," The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, vol.

Intrathecal Resiniferatoxin Modulates TRPV1 in DRG Neurons and Reduces TNF-Induced Pain-Related Behavior

Keller et al., "Prolonged analgesic response of cornea to topical resiniferatoxin, a potent TRPV1 agonist," PAIN, vol.

Corneal Nerve Fiber Structure, Its Role in Corneal Function, and Its Changes in Corneal Diseases

Euphorbium: modern research on its active principle, resiniferatoxin, revives an ancient medicine.

Poisoning by plants in the Taza-Al Hoceima-Taounate region in Morocco

Agents to destimulate the nerve endings, such as lidocaine, resiniferatoxin, and botulinum toxin, have been administered intravesically with some success.

Interstitial cystitis can pose major clinical conundrum: about 700,000 people may have interstitial cystitis, but diagnostic criteria remain in dispute

Intravesical therapies with verapamil, lidocaine, and oxybutynin as well as newer agents of resiniferatoxin and capsaicin are effective but more inconvenient.

Urologic Considerations in MS

Sorrento Therapeutics announced that review of early results from an on-going "declawed cat pain trial" prompted management to assign a high priority to exploring the use of resiniferatoxin as a local nerve block injection for the control of neuropathic post-amputation residual limb pain in humans.

Sorrento Therapeutics to accelerate human IND filing of resiniferatoxin

Petho, "Effect of CP-96,345 a nonpeptide substance P antagonist, capsaicin, resiniferatoxin and ruthenium red on nociception," Regulatory Peptides, vol.

Quantitative Thermal Testing Profiles as a Predictor of Treatment Response to Topical Capsaicin in Patients with Localized Neuropathic Pain

Bradley Jr., "Memory of pain: the effect of perineural resiniferatoxin," Anesthesia & Analgesia, vol.

Inhibition of the cAMP/PKA/CREB Pathway Contributes to the Analgesic Effects of Electroacupuncture in the Anterior Cingulate Cortex in a Rat Pain Memory Model

Scintilla's lead program is resiniferatoxin for the treatment of intractable cancer pain.

M and A Navigator: Deal pipeline -16 August

Sorrento is also producing resiniferatoxin, a non-opiate TRPV1 agonist presently in a Phase I/II trial at the NIH to treat terminal cancer patients suffering from intractable pain.