The dual-bronchodilator combination was also superior to salmeterol-fluticasone when it came to other outcomes, such as respiratory-related health status and rescue medication
use, and it had a good safety profile.
number of nights in a week patient awakened due to asthma symptoms as per history); use of rescue medication
(Number of salbutamol puffs patient required per week) were used to assess efficacy of device at monthly intervals for two months.
1.6), and fewer days with rescue medication
use (1.59 vs.
Patients were allowed to have 5 mg IV nalbuphine as a rescue medication
at any time.
Prolonged time to first use of rescue opioid, with median time to rescue medication
of 4.2 hours with Exparel vs 0.6 hours with placebo.
Clinical, PFT, use of rescue medication
and nocturnal awakening due to asthma symptoms was assessed and compared between pre intervention and post intervention.
Of special concern was the finding that most of the children in this study had a preexisting diagnosis of epilepsy, yet only half received a rescue medication
in the outpatient setting.
All were given antacid tablets to be used as rescue medication
if they developed acid-related symptoms during the study.
Among the nine subjects who used their rescue medication
during the study, medication was used on 54 occasions (a median of 5 times per subject).
Loratidine 10 mg was used as rescue medication
throughout the study, when subjects considered symptoms intolerable.