reproductive toxicity


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reproductive toxicity

Any adverse effect attributable to exposure to a chemical, directed against the reproductive and/or related endocrine systems Adverse effects Altered sexual behavior, fertility, pregnancy outcomes, or modifications in other functions that depend on reproductive integrity of system. See Teratogenicity.
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A general testing ban on cosmetic ingredients from March 11, 2009, reinforced for 10 animal test requirements by an instant marketing ban, as well as a marketing ban for the more complex endpoints (those requiring repeated substance application, e.g., repeated dose toxicity, sensitization, reproductive toxicity, carcinogenicity and toxicokinetics), went into effect March 11, 2013.
Regulatory acceptance and use of the Extended One Generation Reproductive Toxicity Study within Europe.
Interruptions in intrauterine development, when usnic acid was administered at 25 mg/kg, were similar to reproductive toxicity studies of Duguetia furfuracea extracts.
While they lacked definitive information on the toxicity of the majority of the chemicals, the team members analyzed 240 substances and concluded that 157 of them--chemicals such as arsenic, benzene, cadmium, lead, formaldehyde, chlorine, and mercury--are associated with either developmental or reproductive toxicity. Of these, 67 were of particular concern because they had an existing Federal health-based standard or guideline.
Also Chrysin (CR), which is one of a flavonoid that naturally exists in propolis can mitigated the side effects of acute Paracetamol (PRC) reproductive toxicity in male which caused decreased the sperm motility, and increased dead sperm rate, abnormal sperm cell rate [51].
To the best knowledge of the authors, few studies are available on the reproductive toxicity of sildenafil associated with the hormonal changes and the testicular histological alterations induced by this drug.
Some are known to cause reproductive toxicity at high levels of exposure but the link between low-level exposure and BBP had not yet been thoroughly explored.
Parabens, which are commonly used as a preservative in cosmetics, among other products, mimic estrogen and may cause endocrine disruption and reproductive toxicity.
Among these are the CRO's capabilities (with respect to conducting studies on drug metabolism/PK; bioanalysis (preclinical and clinical); and genetic toxicity; repeated-dose toxicity and reproductive toxicity determinations).
[26.] Abdou HM, Newairy AA (2006) Hepatic and Reproductive toxicity of lead in female rats and attenuation by flaxseed lignans.

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