Many gerontologists are studying how silencing and other mechanisms such as telomere shortening influence replicative senescence
Moreover, most cells in the body do not divide, so in their case, replicative senescence
is not a likely cause of aging.
Similarly, SIRT4 and ROS are upregulated during replicative senescence and in response to DNA damage [144, 145]; however, one study shows that SIRT4 depletion reduces ROS  and therefore suggests that inhibiting SIRT4 may be a strategy to prevent oxidative stress in MSCs, while another believes that SIRT4 is required for appropriate recovery from cellular stresses .
Seluanov, "Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence," Proceedings of the National Academy of Sciences of the United States of America, vol.
Friguet, "Protein modification and replicative senescence of WI-38 human embryonic fibroblasts," Aging Cell, vol.
The mitochondrial lncRNA ASncmtRNA-2 is induced in aging and replicative senescence in Endothelial Cells," Journal of Molecular and Cellular Cardiology, vol.
Minet and Gaster  demonstrated that replicative senescence results in decreased mitochondrial mass and ATP content in myotubes while mitochondrial ATP synthesis rate normalized to mitochondrial protein was unchanged.
Our data presents that the activity of AK decreased significantly during replicative senescence of myoblasts, which has not been shown before.
Research on the effects of telomerase on Werner syndrome cells was conducted by scientists at Geron and published in the April issue of the FASEB Journal in a paper entitled "Telomerase expression prevents replicative senescence
but does not fully reset mRNA expression patterns in Werner syndrome cell strains.
Recent experiments have shown that cell transfection with oligonucleotides identical to the mammalian telomeric repeating sequence, 5'-d(TTAGGG)-3', increases the replicative capacity of a variety of phenotypically normal cell types, consistent with the "telomere hypothesis" to explain replicative senescence
has also previously been implicated in atherosclerosis, an age-related cardiovascular disease," stated Dr.
HDF's are somatic (non-reproductive) cells used by Geron to study replicative senescence