replicative senescence

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replicative senescence

a limitation in the number of times that cells can divide; appears to be a basic feature of somatic cells except for most tumor cells and possibly some stem cells. The cell division s counting mechanism is posited to exist as a consequence of a telomere-shortening hypothesis.
Farlex Partner Medical Dictionary © Farlex 2012


(se-nes'ens) [L. senescens, growing old]
1. The process of growing old.
2. The period of old age.

premature senescence

Aging (typically of cells, but also of whole organisms) that occurs much earlier than is expected under healthy or optimal conditions.

replicative senescence

Hayflick's limit.
Medical Dictionary, © 2009 Farlex and Partners
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References in periodicals archive ?
Zeng, "Human embryonic stem cells: mechanisms to escape replicative senescence?," Stem Cell Reviews, vol.
Seluanov, "Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence," Proceedings of the National Academy of Sciences of the United States of America, vol.
Our data presents that the activity of AK decreased significantly during replicative senescence of myoblasts, which has not been shown before.
The present case demonstrated significant pathology in the adjoining mucosa, which pointed toward a replicative senescence.
We used PCR to measure relative TL at PD upon replicative senescence (46 PD) and acrolein-induced senescence (30 PD) in HFL-1 cells and the equivalent PD (30 PD) in vehicle (sterile water) control HFL-1 cells.
The proliferative lifespan of cells is limited by replicative senescence during which the cells permanently withdraw from the cell cycle, yet remain viable [79, 80].
It is caused by null mutations at WRN locus, which codes for a member of RecQ family of DNA helicases.6-9,11 The disease is associated with excessive synthesis of collagen type I and III which is dependent on elevated messenger RNA(mRNA) levels.6 The locus of Werner Syndrome has been found on the short arm of chromosome 8 in both Japanese and non Japanes.5,7,11 Fibroblasts isolated from WS patients exhibit genomic instability, increased sensitivity to specific DNA damaging agents, slow proliferation, lengthened S-phase, and accelerated replicative senescence.5,7,16
However, after attaining reproductive ability the replicative rate slows down gradually, leading to replicative senescence and quiescence which is evident as decreased TSR values.
Replicative senescence of human endothelial cells in vitro envolves G1 arrest, polyploidization and.
This special aspect of cellular senescence is known as replicative senescence.
At "physiological" concentrations, reactive oxygen species (ROS) may play adaptive roles as signalling molecules involved in gene regulation, cell growth, differentiation, replicative senescence and apoptosis (cell death), and as a primary defence invoked by white blood cells against invading organisms.
Astonishingly, many of the genes responsible for replicative senescence in eukaryotes (such as paramecia and yeast) that emerged a billion or more years ago are still present in human beings today.