replicative senescence

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replicative senescence

a limitation in the number of times that cells can divide; appears to be a basic feature of somatic cells except for most tumor cells and possibly some stem cells. The cell division s counting mechanism is posited to exist as a consequence of a telomere-shortening hypothesis.


(se-nes'ens) [L. senescens, growing old]
1. The process of growing old.
2. The period of old age.

premature senescence

Aging (typically of cells, but also of whole organisms) that occurs much earlier than is expected under healthy or optimal conditions.

replicative senescence

Hayflick's limit.
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References in periodicals archive ?
Many gerontologists are studying how silencing and other mechanisms such as telomere shortening influence replicative senescence.
Telomeres shorten with each cell division eventually leading to replicative senescence, a process thought to be associated with age-related decline in immune function.
During the progression of HIV disease, certain immune cells called CD8 + cytotoxic T-cells undergo accelerated replicative senescence (cellular aging), and lose their ability to proliferate and kill HIV-infected CD4+ T-cells.
First, a variety of human cell types grown in culture exhibit little or no telomerase activity, gradual telomere loss, and a finite lifespan culminating in replicative senescence associated with loss of normal differentiated function.
When telomeres become critically short after many rounds of cell division, the cell enters a state known as replicative senescence.