replicative intermediate

rep·li·ca·tive in·ter·me·di·ate

during the copying of the viral RNA of an RNA virus, the opposite sense strand that serves as a template for positive strand production.
References in periodicals archive ?
HCV RNA-negative strand is a replicative intermediate in the viral life cycle and is generally accepted as evidence of ongoing HCV replication (Hepatology 2005;41:106-14).
In mouse models of HBV infection, a single injection of ARC-520 containing NAG-polymer and chol-siRNAs targeting conserved regions of the HBV transcripts resulted in multi-log reductions in circulating viral antigens and HBV DNA, and dramatically reduced HBV RNA and DNA replicative intermediates in the liver.