replacement fibrosis

re·place·ment fi·bro·sis

the formation of fibrous tissue that occupies sites where various other cells and tissues have become atrophied, degenerated, and necrotic.
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The hallmarks of AF cardiomyopathy (increasing wall thickness, regional functional abnormalities, and replacement fibrosis) during aging are not the same for both sexes.
These factors lead to the development of changes in cardiac structure and function including left ventricular hypertrophy (LVH), left ventricular (LV) dilatation, diffuse myocardial fibrosis (DMF), and replacement fibrosis (myocardial scarring) [5].
(3) Replacement fibrosis is scarring that occurs after cardiomyocyte damage or once myocardial cell integrity has been affected.
Imaging techniques that allow safe, reliable, early detection of MF may improve disease risk stratification, be an important imaging biomarker in clinical research studies, and allow early treatment to prevent/slow progression to replacement fibrosis or even reverse it.
(8,9) Histologic examination of the left ventricular myocardium has shown variable features from myocyte necrosis to replacement fibrosis and endocardial fibroelastosis.
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