reperfusion therapy

Cardiology Any therapy–eg, thrombolytic therapy-tPA, stenting, or immediate percutaneous transluminal coronary angioplasty-IPCTA–intended to ensure continued blood flow–and oxygenation through a vascular bed acutely compromised by vasospasm or thrombosis, especially post acute MI. See tPA, Trials.

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Previous studies have shown that an important gap still exists between the clinical performance of timely reperfusion therapy and the guideline-recommended timing for patients with STEMI.

HEART FAILURE IN PATIENTS WITH SEGMENT ELEVATION MYOCARDIAL INFARCTION UNDERGOING PRIMARY PCI AND ITS ASSOCIATION WITHISCHEMIC TIME

A targeted neurological (National Institute of Health Stroke Score (NIHSS)) and cardiovascular examination and rapid blood glucose test should be performed before the start of reperfusion therapy. Further work-up, including blood investigations, an electrocardiogram (ECG) and a chest radiograph, should not delay treatment.

Medical management of acute ischaemic stroke

The proposed time windows system goal, for any individual patient every effort should be made to provide reperfusion therapy as rapidly as possible.

Speakers discuss Diagnosis and Management of Acute Coronary Syndrome

For predicting high-risk stratification and reperfusion therapy, the qSOFA-ECG is superior to PE Severity Index (PESI) and simplified PESI.

Contribution of Quick Sequential Organ Failure Assessment Score Combined with Electrocardiography in Risk Stratification of Patients with Acute Pulmonary Embolism

Measurements on admission (baseline) were not taken in this group as they delay reperfusion therapy. Mean difference among measurement of MPI was highest between discharge and six-month interval.

AN ECHOCARDIOGRAPHY ASSESSMENT OF RIGHT VENTRICULAR FUNCTION IN INFERIOR WALL MYOCARDIAL INFARCTION UNDERGOING PRIMARY PTCA VS. PTCA WITHIN ONE MONTH OF INDEX EVENT- A FOLLOW-UP STUDY

de Winter and Wellens pointed out the importance of recognizing the equivalents of acute MI with ST elevation and need for emergency reperfusion therapy. After analyzing data obtained from the database of PCIs, ECG on the first contact with the patient, ECG before treatment, findings of coronary angiography, they described ECG pattern found in approximately 2% of patients with angiography proven anterior MI with occlusion of the anterior descending coronary artery [8].

ATYPICAL ELECTROCARDIOGRAPHIC PRESENTATIONS OF MYOCARDIAL INFARCTION WITH ST ELEVATION - ST ELEVATION MYOCARDIAL INFARCTION EQUIVALENTS/ATIPICNI ELEKTROKARDIOGRAFSKI PRIKAZI INFARKTA MIOKARDA SA ST ELEVACIJOM--EK-VIVALENTI INFARKTA MIOKARDA SA ELEVACIJOM ST SEGMENT A

If reperfusion therapy is not appropriate, then the focus is on management to minimize further damage from the stroke, decrease the likelihood of recurrence, and lessen secondary problems related to the stroke.

Early care of patients with acute ischemic stroke

MRAs such as spironolactone and eplerenone can offset the damaging effect of high aldosterone levels - which rise immediately after a heart attack augmenting the benefits of optimal standard therapy including reperfusion therapy, beta-blockers, dual antiplatelet therapy, statins and ACE inhibitors, explained Prof Beygui.

France : Anti-aldosterones save lives in STEMI heart attack patients: pooled ALBATROSS and REMINDER data

While reperfusion therapy has brought new hope for the reduction of myocardial damage, reperfusion itself has been shown to potentially induce a localized oxidative burst and a regional inflammatory response, resulting in cell damage and, in some cases, death.

Kaempferide Protects against Myocardial Ischemia/Reperfusion Injury through Activation of the PI3K/Akt/GSK-3[beta] Pathway

More recent data using propensity scores to compare reperfusion therapy to anticoagulation alone found no significant difference in mortality and bleeding, with a higher risk of recurrence with reperfusion therapy [23].

Pulmonary Embolism and Intracardiac Type A Thrombus with an Unexpected Outcome

Multimodal MRI imaging techniques have been shown to better identify patients that are likely to benefit from endovascular reperfusion therapy. Particularly patients with a significant perfusion/diffusion mismatch on MRI have substantial salvageable brain tissue that can be recovered from ischemia after reperfusion by endovascular treatment, showing better long-term clinical outcome [4].

Successful Mechanical Thrombectomy of a Middle Cerebral Artery Occlusion 14 Hours after Stroke Onset

Reperfusion Therapy with Rapamycin Reduces Infarct Size and Improves Cardiac Function.

Reperfusion Therapy with Rapamycin Attenuates Myocardial Infarction through Activation of AKT and ERK