reperfusion injury


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re·per·fu·sion in·ju·ry

myocardial impairment, usually with arrhythmia, following the opening of arterial blockage and considered to be due to oxygen-derived free radicals.
Cardiology Myocardial injury caused by rapid flow of blood into areas previously rendered ischaemic by coronary artery occlusion. Reperfusion injury is attributed to oxidative stress, which may cause arrhythmia, infarction, myocardial stunning
Traumatology A component of crush syndrome, which occurs when blood flow is re-established to an organ or tissue exposed to prolonged ischaemia; renewed blood flow aggravates tissue damage either by causing additional injury or by unmasking injury sustained during the ischaemic period. Reperfusion injury occurs in the heart, intestine, kidney, lung, and muscle, and is due to microvascular damage

reperfusion injury

Cardiology Myocardial injury caused by rapid flow of blood into areas previously rendered ischemic by coronary artery occlusion; RI is attributed to oxidative stress, which may cause arrhythmia, infarction, myocardial stunning. See Reperfusion Traumatology A component of crush syndrome, which occurs when blood flow is reestablished to an organ or tissue exposed to prolonged ischemia; renewed blood flow aggravates tissue damage either by causing additional injury or by unmasking injury sustained during the ischemic period; RI occurs in the heart, intestine, kidney, lung, and muscle, and is due to microvascular damage. See Calcium paradox, Oxygen paradox.

reperfusion injury

The damage, and loss of function, that commonly occurs in the heart muscle when, after a heart attack, the flow of blood to the muscle is restored. Reperfusion injury is generally agreed to be due mainly to the action of oxygen FREE RADICALS. It is also known as myocardial stunning.

reperfusion injury

damage to renal blood vessels during periods of hypotension does not become apparent until reperfusion occurs in the recovery stage of the vascular incident.
References in periodicals archive ?
The current study was planned to evaluate the kinetics and the association of some markers of myocardial necrosis and apoptosis in patients during reperfusion injury who underwent either primary PCI or received thrombolysis therapy with STEMI-ACS.
Kurian, "Hydrogen sulfide post-conditioning preserves interfibrillar mitochondria of rat heart during ischemia reperfusion injury," Cell Stress and Chaperones, 2016.
23 determined a significant reduction in IR injury in rats administered with 10-20mL/ kg HES for kidney ischaemia and reperfusion injury and reported that the reduction could be related to the adherence between neutrophils and the endothelium achieved with reduced ICAM-1 expression.
Ischemia Reperfusion Injury - Pipeline Review, H2 2014
The last type is the lethal reperfusion injury that consists of death of the cardiomyocytes after reperfusion [1].
Coverage of the Reperfusion Injury pipeline on the basis of route of administration and molecule type.
As might be expected, inhibitors of oxidative stress provide significant beneficial effect on testicular ischemia reperfusion injury (21).
Reduction of reperfusion injury with preoperative rapid intravenous infusion of taurine during myocardial revascularization.
Further, we demonstrated in our previous study that DNA content and decrease cytochrome P 450 in ischemia and reperfusion injury, presumably as a result of increase activity of TNF-a by toxic effect of ischemia and reperfusion.
Although it is necessary to preserve or restore heart function, it can paradoxically cause a disturbance in the function of the cells in the heart muscle, called reperfusion injury.