Pulpal wound healing, including reparative dentin
formation, is a complex multifactorial process orchestrated by discrete but overlapping steps of migration, proliferation, and mineralization of pulp cells, (1) formed by odontoblast-like cells presumably differentiated from DPSCs.
improved sealing properties and greater ability to stimulate reparative dentin
formation compared with Ca(OH)2.
Ruggeri et al., "In vitro reparative dentin
: A biochemical and morphological study," European Journal of Histochemistry, vol.
With age, secondary dentin and reparative dentin
continue to deposit, so many scholars select secondary dentin deposition as an age-related research indicator, but this study can only be carried out on the corpse (Bommannavar & Kulkarni, 2015; Chopra et al., 2015; Kaur, et al., 2015; Klumb et al., 2016).
The dental pulp is isolated from the lesion by the defensive response of a mature odontoblast, which produces secondary and reparative dentin
in response to external physiological and pathological stimuli.
Calcium hydroxide has long been the gold standard among direct pulp capping materials for its antibacterial properties and ability to stimulate formation of a reparative dentin
barrier (1, 2).
These odontoblasts promote deposition of reparative dentin
over a period of few weeks [9,10].
Although the regenerative process of the dentin/pulp complex is not well understood, it is known that the reparative dentin
is deposed as a protective barrier for the pulp as a consequence of trauma or cavity [4, 5].
Only 2 patients in 35-50 years age group presented with pain because with advancing age, a reduction in pulp chamber volume and relative constriction of occluso-gingival reduction occurs due to an increased secondary and reparative dentin
formation in rat molars after direct pulp capping with growth factors.
Moreover, the typical reparative dentin
bridge seen in human teeth was not as readily apparent in the minute rodent teeth, owing to the technical challenges with the procedure.
These findings indicated the potential use of ginsenoside Rgl in endodontic biotherapy, reparative dentin
formation and tooth tissue engineering.