For many years, scientists have known that viruses rely on functions provided by their host cells to increase their numbers, but the UCI study - led by microbiology and molecular genetics professor Bert Semler - is the first to identify how the RNA-containing picornaviruses utilize a DNA repair enzyme
to do so.
The human OGG1 DNA repair enzyme
and its association with orolaryngeal cancer risk.
These results are similar to data obtained with the DNA repair enzyme
Ogg1 and indicate the dependence of inhibition on the presence of free metal ions in solution (Zharkov and Rosenquist 2002).
com)-- In real life, the discovery of telomerase, the DNA repair enzyme
for all plants and animals, was awarded the 2009 Nobel Prize in Medicine.
coli DNA repair enzyme
, MutM, has been shown to remove 7,8-dihydro-8-oxoguanine (8-oxoG), an oxidatively damaged form of guanine nucleotide.
Other experiments demonstrated that the actual telomeres in blood cells of caregivers were shorter than those of the controls, and that the level of telomerase repair enzyme
among caregivers was lower.
Several SNPs and somatic mutations have been characterized in a human 8-hydroxyguanine glycosylase gene, OGG1, which codes for a DNA repair enzyme
responsible for excising 8-hydroxyguanine from damaged DNA (1, 2).
has announced that the National Cancer Institute intends to conduct a one-year clinical trial of its Dimericine, a topical liposomal DNA repair enzyme
, to reduce the rate of skin cancer in renal transplant patients.
The generalized repair enzyme
system, says Britt, is probably designed for a wide variety of relatively rare types of damage.
DelMar has demonstrated that VAL-083's anti-tumor activity is unaffected by the expression of MGMT, a DNA repair enzyme
that is implicated in chemotherapy resistance and poor outcomes in GBM patients following standard front-line treatment with temozolomide.
Mark Glover, his graduate student Zahra Havali-Shahriari and post-doctoral fellow Nicolas Coquelle solved the structure of a DNA repair enzyme
called polynucleotide kinase/phosphatase, or PNKP.
Only one focused on xeroderma pigmentosa: The 30-patient trial showed reductions in new actinic keratoses and BCCs during 1 year of topical T4N5, a repair enzyme
specific for UV-induced DNA damage.