renal tubular necrosis
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Acute Tubular NecrosisA condition characterised by acute renal failure with oliguria, which returns to normal in days to weeks, with the caveat that 50% of patients die.
Aetiology Ischaemia—medical, obstetric, surgical, including transplantation (cold ischaemia); toxicity—drugs (aminoglycosides, amphotericin B, cyclosporine), chemicals (radiocontrast), pigments (myoglobin—crush syndrome, haemoglobinuria), sepsis, shock. Predisposing conditions Diabetes, liver disease, immunosuppression by toxic agents.
Management It is managed in transplanted kidneys in an expectant fashion as renal function may resume spontaneously in 2 to 4 weeks.