renal tubular necrosis


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Acute Tubular Necrosis

A condition characterised by acute renal failure with oliguria, which returns to normal in days to weeks, with the caveat that 50% of patients die.
Aetiology Ischaemia—medical, obstetric, surgical, including transplantation (cold ischaemia); toxicity—drugs (aminoglycosides, amphotericin B, cyclosporine), chemicals (radiocontrast), pigments (myoglobin—crush syndrome, haemoglobinuria), sepsis, shock. Predisposing conditions Diabetes, liver disease, immunosuppression by toxic agents.
Management It is managed in transplanted kidneys in an expectant fashion as renal function may resume spontaneously in 2 to 4 weeks.

renal tubular necrosis

See Acute tubular necrosis.
References in periodicals archive ?
Ingestion of PPD causes rapid development of oedema of the face, neck, pharynx, tongue and larynx initially and then rhabdomyolysis.10 Finally acute renal failure results from renal tubular necrosis due to deposits of the toxic metabolites of PPD.11 PPD is found in almost all brands of commercially available hair dyes.10 PPD is active ingredient of Kala Pathar (Meaning Black Stone in Urdu).12 The compound PPD is highly toxic when taken orally.
In experimental group B there was statistically significant difference (p-value less than 0.001 in levels of renal tubular necrosis (15% animals) and grades of vacuolar degeneration (5% animals) as compared to experimental group A.
The bilirubin crystal could result in renal medulla, renal interstitium, and renal tubular necrosis in patients with hyperbilirubinemia.

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