renal clearance


Also found in: Dictionary, Encyclopedia, Wikipedia.
Related to renal clearance: renal clearance test

renal clearance

n.
The volume of plasma completely cleared of a specific compound per unit time and measured as a test of kidney function.

renal clearance

Therapeutics A hypothetical calculation of plasma volume in liters of unmetabolized drug cleared through the kidneys/unit time Factors influencing RC Renal blood flow, urinary pH, tubular resorption and secretion
References in periodicals archive ?
Influence of plasma drug concentration, diuresis and urine pH on renal clearance of the cefixime was analysed by regression/correlation method at p0.05) (Figure-2a), a non-significant positive correlation with the renal clearance of cefixime (p>0.05) (Figure-2b).
The increase in prolactin levels in patients on RRT could be partly explained by reduced renal clearance of prolactin [2, 3].
Escitalopram is the (S)-enantiomer of the racemic antidepressant citalopram, both of which have been shown to decrease renal clearance in patients with mild or moderate renal impairment.
Full-dose simeprevir was likely acceptable since renal clearance plays an insignificant role (<1%) in the elimination of simeprevir [9].
However, it is important to note that interpreting elevations in troponin T is a challenge in patients who have kidney impairment, because the problem may impair renal clearance of troponin.
In vivo renal clearance, biodistribution, toxicity of gold nanoclusters.
This clinical phenomenon has now been termed augmented renal clearance (ARC).[14] In such circumstances all renally eliminated drugs will have increased clearances.
In vivo studies have demonstrated that cyclosporine inhibits hepatic and renal clearance of colchicine, thus increasing serum colchicine levels, further lowering the toxic colchicine dose.
The renal clearance of drug is blood flow dependent, so the elimination by the kidney can be impaired when reduced cardiac output compromises renal blood flow [24].
The increased renal clearance of LTFS may occur owing to impaired kidney filtration function.
The renal clearance ([Cl.sub.r]) was calculated as the 12 h cumulative amount of analyte in urine divided by the plasma AU[C.sub.0-12h].