RCC1

(redirected from regulator of chromosome condensation)

RCC1

A gene on chromosome 1p36.1 that encodes a guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. The RCC1 protein product helps regulate the onset of S-phase chromosome condensation, binding to nucleosomes and double-stranded DNA. The RCC1-Ran complex with other proteins is part of a signal transmission pathway that detects unreplicated DNA. RCC1 plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.
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Makde, a postdoctoral member of the research team led by Tan, grew molecular crystals of the protein RCC1 (regulator of chromosome condensation, a protein critical for proper separation of chromosomes during cell division) bound to the nucleosome, and used X-ray crystallography to determine the atomic structure of the complex.