regulator gene


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gene

 [jēn]
one of the biologic units of heredity, self-reproducing, and located at a definite position (locus) on a particular chromosome. Genes make up segments of the complex deoxyribonucleic acid (DNA) molecule that controls cellular reproduction and function. There are thousands of genes in the chromosomes of each cell nucleus; they play an important role in heredity because they control the individual physical, biochemical, and physiologic traits inherited by offspring from their parents. Through the genetic code of DNA they also control the day-to-day functions and reproduction of all cells in the body. For example, the genes control the synthesis of structural proteins and also the enzymes that regulate various chemical reactions that take place in a cell.

The gene is capable of replication. When a cell multiplies by mitosis each daughter cell carries a set of genes that is an exact replica of that of the parent cell. This characteristic of replication explains how genes can carry hereditary traits through successive generations without change.
allelic gene allele.
complementary g's two independent pairs of nonallelic genes, neither of which will produce its effect in the absence of the other.
DCC gene (deleted in colorectal carcinoma) a gene normally expressed in the mucosa of the colon but reduced or absent in a small proportion of patients with colorectal cancer.
dominant gene one that produces an effect (the phenotype) in the organism regardless of the state of the corresponding allele. An example of a trait determined by a dominant gene is brown eye color. See also heredity.
histocompatibility gene one that determines the specificity of tissue antigenicity (hla antigens) and thus the compatibility of donor and recipient in tissue transplantation and blood transfusion.
holandric g's genes located on the Y chromosome and appearing only in male offspring.
immune response (Ir) g's genes of the major histocompatibility complex that govern the immune response to individual immunogens.
immune suppressor (Is) g's genes that govern the formation of suppressor T lymphocytes.
immunoglobulin g's the genes coding for immunoglobulin heavy and light chains, which are organized in three loci coding for κ light chains, λ light chains, and heavy chains.
K-ras gene a type of oncogene.
lethal gene one whose presence brings about the death of the organism or permits survival only under certain conditions.
major gene a gene whose effect on the phenotype is always evident, regardless of how this effect is modified by other genes.
mutant gene one that has undergone a detectable mutation.
operator gene one serving as a starting point for reading the genetic code, and which, through interaction with a repressor, controls the activity of structural genes associated with it in the operon.
gene pool all of the genes possessed by all of the members of a population that will reproduce.
recessive gene one that produces an effect in the organism only when it is transmitted by both parents, i.e., only when the individual is homozygous. See also heredity.
regulator gene (repressor gene) one that synthesizes repressor, a substance which, through interaction with the operator gene, switches off the activity of the structural genes associated with it in the operon.
sex-linked gene a gene carried on a sex chromosome (X or Y); only X linkage has clinical significance. See X-linked gene.
structural gene one that forms templates for messenger RNA and is thereby responsible for the amino acid sequence of specific polypeptides.
tumor suppressor gene a gene whose function is to limit cell proliferation and loss of whose function leads to cell transformation and tumor growth; called also antioncogene.
X-linked gene a gene carried on the X chromosome; the corresponding trait, whether dominant or recessive, is always expressed in males, who have only one X chromosome. the term “X-linked” is sometimes used synonymously with “sex-linked,” since no genetic disorders have as yet been associated with genes on the Y chromosome.

reg·u·la·tor gene

a gene that produces a repressor substance that inhibits an operator gene when combined with it. It thus prevents production of a specific protein. When the protein is again in demand, a specific regulatory metabolite inhibits the repressor substance.

regulator gene

n.
A gene that causes the production of a protein that regulates or suppresses the activity of one or more structural genes. Also called regulator, regulatory gene.

reg·u·la·tor gene

(reg'yū-lā'tŏr jēn)
A gene that produces a repressor substance that inhibits an operator gene when combined with it. It thus prevents production of a specific enzyme. When the enzyme is again in demand, a specific regulatory metabolite inhibits the repressor substance.

regulator gene

A gene that codes for RNA or for a protein whose function is to controls the expression of one or more other genes.

regulator gene

see OPERON MODEL.
References in periodicals archive ?
Bornstein et al., "Transcriptional programs that control expression of the autoimmune regulator gene Aire," Nature Immunology, vol.
Autoimmune polyendocrine syndrome type 1 in Norway: phenotypic variation, autoantibodies, and novel mutations in the autoimmune regulator gene. J Clin Endocrinol Metab 2007; 92: 595-603.
Complete gene scanning by temperature gradient capillary electrophoresis using the cystic fibrosis transmembrane conductance regulator gene as a model.
SEATTLE -- An adeno-associated virus has safely delivered a transmembrane conductance regulator gene into the cells of 70 cystic fibrosis patients, Barrie J.
Vertex Pharmaceuticals announced that Health Canada approved PrSYMDEKO for treating the underlying cause of cystic fibrosis in people ages 12 and older who have two copies of the F508del mutation in the cystic fibrosis transmembrane conductance regulator gene, or who have one copy of the F508del mutation and one mutation in the CFTR gene.
(NASDAQ: VRTX) has released positive results from an open-label Phase 3 study of Kalydeco (ivacaftor) in children with cystic fibrosis (CF) ages 1 to 2 years who have one of 10 mutations in the cystic fibrosis transmembrane conductance regulator gene, the company said.
Based on the study's findings, the authors came to the conclusion that host susceptibility to Ebola virus is dependent on the delicate balance of the body's natural immune system, which can be determined by the levels of a single regulator gene.
Variation in a repeat sequence determines whether a common variant of the cystic fibrosis transmembrane conductance regulator gene is pathogenic or benign.
asburiae isolates identified an upstream LysR-type regulator gene that explained inducibility of IMI-2 expression.
- The New England Journal of Medicine (NEJM) has published two articles with results from Boston, Massachusetts-based serious disease therapeutics developer Vertex Pharmaceuticals Inc.'s (NASDAQ: VRTX) two Phase 3 studies of the tezacaftor/ivacaftor combination treatment, a medicine in development to treat the underlying cause of cystic fibrosis (CF) in people ages 12 and older who have certain mutations in the cystic fibrosis transmembrane conductance regulator gene, the company said.
Washington, July 21 (AIN): Identifying a master regulator gene for early embryonic development of the pancreas and other organs, scientists at Cincinnati Children's Hospital Medical Center have moved a step closer to coaxing stem cells into pancreatic cells as a possible cure for type1 diabetes.
Long-range (17.7 kb) allele-specific polymerase chain reaction method for direct haplotyping of R117H and IVS-8 mutations of the cystic fibrosis transmembrane regulator gene. J Mol Diagn 2004;6: 264-70.