The role of an alginate suspension on pepsin and bile acids - key aggressors in the gastric refluxate
Aspiration of even a small amount of a neutral-pH refluxate
causes cough," Koufman explains.
2) LPR is linked to globus by two main mechanisms: (1) vagal reflux stimulation in the esophagus by acidic reflux and (2) mucosal injury in the larynx from direct contact with refluxate
that contains gastric acid and pepsin.
18) This transition usually occurs in the context of chronic gastrooesophageal reflux disease, which causes exposure of the epithelium to refluxate
While many people experience some degree of normal reflux of gastric acid contents, such episodes are generally considered "physiologic," as they are asymptomatic and the refluxate
PPI therapy exclusively targets gastric acid production, but acid is not the only potentially harmful agent in the refluxate
He then talked about nature of gastric refluxate
In the first case, chemical irritants in the gastric refluxate
enter the laryngopharyrnx and cause local mucosal injury.
MII with pH sensor allows the detection of acidic (pH<4), weakly acidic (4[greater than or equal to]pH<7), and weakly alkaline (pH[greater than or equal to]7) reflux and can also determine the characteristics of the gastric refluxate
(gas, liquid, mixed gas and liquid).
The nature and amount of refluxed material, as well as the length of time the refluxate
remains in contact with the esophageal mucosa, determine whether disease develops.
Poor esophageal peristalsis may further impair clearance of acid or non-acid refluxate
, thereby explaining the persistence of symptoms despite maximal medical management.
This study was carried out to evaluate the effect of preanaesthetic oral administration of sodium rabeprazole on pH and volume of gastric contents in adult patients undergoing elective surgery by excluding cases contaminated with duodeno-gastric refluxate