refluxate

(rē-flŭks′āt″)

The acid, gas, and liquid that rise from the upper gastrointestinal tract into the esophagus in gastroesophageal reflux disease. Its components may include gastric acids, bile, and pepsin.

References in periodicals archive ?

The pH of NAR episodes may affect the biological activity of the refluxate content.

Twenty-four-hour oesophageal pH studies in rural Eastern Cape Province, South Africa

Laryngopharyngeal reflux (LPR) and lung aspiration of refluxate are dangerous complications that often occur in the absence of oesophagitis or its primary symptom, heartburn (5).

Benchmarking of a Simple Scintigraphic Test for Gastro-oesophageal Reflux Disease That Assesses Oesophageal Disease and Its Pulmonary Complications/Basit Bir Yontem Olan Gastro-ozefageal Reflu Sintigrafisi ile Ozefagus Hastaligi ve Pulmoner Komplikasyonlarin Degerlendirilmesi

This suggests that gastric refluxate can enter the middle ear and thus contribute to the development of OME.

A Clinical Trial of Proton Pump Inhibitors to Treat Children with Chronic Otitis Media with Effusion

Vagal innervation is also the underlying mechanism for cardiac arrhythmia and ischemia being triggered by esophageal irritation with acidic refluxate, as well as esophageal spasm being triggered by cardiac ischemia (4,5).

THE ROLE OF ENDOTHELIAL DYSFUNCTION IN THE MECHANISM OF GASTROESOPHAGEAL REFLUX DISEASE DEVELOPMENT IN PATIENTS WITH ISCHEMIC HEART DISEASE

The role of an alginate suspension on pepsin and bile acids - key aggressors in the gastric refluxate. Does this have implications for the treatment of gastro-oesophageal reflux disease?

Hidden dangers of heartburn drugs

In addition, decreasing transient lower esophageal sphincter relaxations (TLESRs) can reduce distal acid exposure and weakly acidic refluxate [6].

Efficacy and Safety of Modified Banxia Xiexin Decoction (Pinellia Decoction for Draining the Heart) for Gastroesophageal Reflux Disease in Adults: A Systematic Review and Meta-Analysis

There were also no correlations found between pH levels and RSI 7 "Troublesome or annoying cough" or RSI 2 "Clearing your throat." Cough can not only be triggered by direct contact of the laryngeal mucosa with refluxate, as is the case with LPR, but GERD could cause indirect irritation to the larynx due to esophageal irritation caused by a vagal reflex [44].

Quantifying Laryngopharyngeal Reflux in Singers: Perceptual and Objective Findings

"Aspiration of even a small amount of a neutral-pH refluxate causes cough," Koufman explains.

Acid reflux, asthma, and recalcitrant cough

(2) LPR is linked to globus by two main mechanisms: (1) vagal reflux stimulation in the esophagus by acidic reflux and (2) mucosal injury in the larynx from direct contact with refluxate that contains gastric acid and pepsin.

Globus sensation and laryngopharyngeal reflux

(18) This transition usually occurs in the context of chronic gastrooesophageal reflux disease, which causes exposure of the epithelium to refluxate. Gastro-oesophageal reflux disease is a major contributory factor and 5% of people with reflux disease develop Barrett's oesophagus.

Current management of oesophageal cancer

While many people experience some degree of normal reflux of gastric acid contents, such episodes are generally considered "physiologic," as they are asymptomatic and the refluxate rapidly clears.