ET is a rare, chronic blood cancer characterized by increased platelet production, a white cell count above the normal range, persistently elevated platelet counts with normal red blood cell mass
, and the absence of prominent bone marrow fibrosis.
Rapid restoration of red blood cell mass
in severely anemic surgical patients who refuse transfusion.
Although the mechanism behind this association is unclear, it has been hypothesised that this is due to the reduced red blood cell mass and the lower preoperative haemoglobin level following predonation which may result in reduced blood viscosity.
Perioperative administration of erythropoietin has also been shown to enhance red blood cell mass (Klein 1995, Spence et al 1995).
The increase in plasma volume is proportionally greater than the increase in red blood cell mass
and so red blood cell concentration levels appear low without representing true anemia.
A prolonged stay in space results in a decrease in blood volume and red blood cell mass
, muscle atrophy, a loss of bone mass, and autonomic system disturbance causing orthostatic intolerance.
The athlete winds up with increased red blood cell numbers and higher red blood cell mass
3 Red blood cell mass will not increase without supplements of elemental iron.
The goal of altitude training is to build greater red blood cell mass and more hemoglobin to grab the limited diffused [0.sub.2] molecules.