recombination

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recombination

 [re″kom-bĭ-na´shun]
1. the reunion, in the same or different arrangement, of formerly united elements that have been separated.
2. in genetics, the process that creates new combinations of genes by shuffling the linear order of the DNA, such as occurs naturally by crossing over of homologous chromosomes during meiosis or of homologous DNA sequences in somatic cells during mitosis, or occurs in vitro when DNA or RNA is manipulated for genetic engineering.
bacterial recombination in bacterial genetics, the process of producing a new gene by any of several processes, e.g., the sexual union of two parents, molecular crossing over between two DNA chains, or transformation.

re·com·bi·na·tion

(rē-kom'bi-nā'shŭn),
1. The process of reuniting parts that had become separated.
See also: recombinant.
2. The reversal of coupling phase in meiosis as gauged by the resulting phenotype.
See also: recombinant.
3. The formation of new combinations of genes.

recombination

(rē′kŏm-bə-nā′shən)
n.
The natural or artificial rearrangement of genetic material in living organisms or viruses, especially the creation in offspring of sexually reproducing parents of new combinations of genes through the process of crossing over during meiosis.

re·com·bi·na·tion

(rē-kom'bi-nā'shŭn)
1. The process of reuniting of parts that had become separated.
2. The reversal of coupling phase in meiosis as gauged by the resulting phenotype.
See also: recombinant

recombination

The formation in offspring of a combination of two or more genes that differs from the arrangement of these genes in either parent. This is the result of the exchange of segments of DNA during the germ cell divisions that resulted in the formation of paternal sperms and maternal ova.
Recombinationclick for a larger image
Fig. 266 Recombination . The rearrangement of genes during meiosis.

recombination

  1. a rearrangement of genes during MEIOSIS so that a GAMETE contains a haploid GENOTYPE with a new gene combination. Recombination can occur by INDEPENDENT ASSORTMENT of genes on different chromosomes, but the term is used normally to refer to genes linked on the same chromosome where recombination is achieved by CROSSING OVER. See Fig. 266 .
  2. any exchange between DNA molecules or integration of one DNA molecule into another.
References in periodicals archive ?
Molecular phylogeny of hepatitis B virus in Laos revcals multiple subtypes of endemic genotypes, numerous unclassifiable strains and a growing prevalence of recombinations within sub- and genotypes and a potential new genotype.
Phylogenetic analysis of the precore/core gene of hepatitis B virus gcnotypes E and A in West Africa: new subtypes, mixed infections and recombinations. J Gen Virol.
PCR analysis using primers revealed the gtfB-gtfC region of RRA1, a mutant isolated from MT8148 grown overnight with rRecA added, and clinical strains SP2 and NN2051, which possessed gtfBC recombination and developed smooth colonies.
"For the first time, we were able to generate an individual recombination map and mutation rate for each of several sperm from one person," said study co-author Barry Behr, PhD, HCLD, professor of obstetrics and gynecology and director of Stanford's in vitro fertilization laboratory.
Under the assumption that underlies Haldane's mapping function that recombination events are independent across the genome, the number of recombinations for a progeny is Poisson distributed with mean and variance equal to the map size of the genome in Morgans.
In the history of science, a twofold process can be seen: a fragmentation of formal disciplines and a recombination of the specialties resulting from this fragmentation.
Recombination was further analyzed by Bootscan, a program for the detection of recombination events, and the Genetic Algorithm for Recombination Detection (GARD) (13).
Let us denote by [Delta](d) an inverse mapping function that converts a map distance d, given in morgans, to a recombination fraction r.
However, a recombination heterogeneity by inbreeding method interaction indicated that the difference between methods in locus aggregation occurred only under homogeneous but not heterogeneous recombination frequencies [MATHEMATICAL EXPRESSION NOT REPRODUCIBLE IN ASCII] = 4.5; P [is less than] 0.05).
The chimeric nature of the virus strain was confirmed by RT-PCR with primers spanning possible recombination sites and analysis of overlapping reads from next-generation sequencing.
Our goals were 1) to characterize the diversity of circulating rhinoviruses and, to a lesser extent, enteroviruses, to identify putative new picornavirus variants, and 2) to assess whether recombination may drive HRV evolution, which has not been shown in natural human infections (18).