recombination repair


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recombination repair

The process of making good a gap in one strand of DNA by plugging it with a homologous strand taken from another length of double helix.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
When the investigators added a PARP inhibitor to suppress homologous recombination repair after radiation, DNA repair capacity in irradiated ARID1A mutated cancer cells was thwarted, since both the NHEJ and homologous recombination mechanisms were defective.
United Kingdom-based AstraZeneca and United States-based MSD have revealed positive results from the Phase III PROfound trial of Lynparza (olaparib) in men with metastatic castration-resistant prostate cancer who have a homologous recombination repair gene mutation and have progressed on prior treatment with new hormonal anticancer treatments, it was reported yesterday.
inside the US and Canada) today announced positive results from the Phase III PROfound trial of Lynparza (olaparib) in men with metastatic castration-resistant prostate cancer (mCRPC) who have a *homologous recombination repair gene mutation (HRRm) and have progressed on prior treatment with new hormonal anticancer treatments (e.g.
AstraZeneca (AZN) and Merck (MRK) announced results from the Phase 3 PROfound trial of Lynparza in men with metastatic castration-resistant prostate cancer - mCRPC - who have an homologous recombination repair gene mutation and have progressed on prior treatment with new hormonal anticancer treatments.
Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the homologous recombination repair in colorectal cancer- a case control study.
Induced base oxidative damage (i.e., 8-oxoG) in DNA is counteracted by base excision repair (BER), as well as by components of mismatch repair (MMR) and nucleotide excision repair (NER) pathways in connection to the recombination repair pathway (14, 30 for review, 34-37).
Homologous recombination repair ensures the damage removal with simultaneous exact reproduction of the original sequence of the modified DNA.
In mammalian cells, numerous predominant DNA repair mechanisms are well analyzed, such as direct repair, base excision repair (BER), nucleotide excision repair (NER), mismatch repair, homologous recombination repair (HR), and non-homologous end-joining repair (NHEJ) [11].
Polymorphisms in RAD51, [XRCC.sub.2] and [XRCC.sub.3] genes of the homologous recombination repair in colorectal cancer a case control study.
However, these include recombination repair by RuvB [222], nucleotide excision repair by UvrC [223], and deaminated base excision repair by endonuclease V [224].
Homologous recombination repair of DSBs is essential for making error-free genetic information from a homologous undamaged DNA molecule.