recombinase


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recombinase

(rē-kŏm′bə-nās′, -nāz′)
n.
An enzyme that catalyzes the exchange of short pieces of DNA between two long DNA strands, particularly the exchange of homologous regions between the paired maternal and paternal chromosomes.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

recombinase

(rē-kŏm′bĭn-ās) [ recombinan(t) + ″]
Any enzyme that catalyzes nucleic acid recombination, i.e., the rearrangement of genetic material on a strand of DNA or RNA.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Recombinases, nucleases, and accessory proteins are natural or artificially created tools for gene editing that are used for developing powerful methods of genetic engineering.
pCP20###Ampr,Cmr; Flp recombinase expression###Datsenko and Wanner (2000); Duan et al.
[3] Nonstandard abbreviations: SFTS, severe fever with thrombocytopenia syndrome; SFTSV, SFTS virus; IFA, immunofluorescence assays; RT, reverse transcription; iNAD, isothermal nucleic acid amplification procedure with bio-optical sensor detection; SMR, silicon microring resonator; RPA, recombinase polymerase amplification; cDNA, complementary DNA.
However, one has to keep in mind that during in vitro DC development, a relatively late onset of Cre recombinase occurs, so that the role of CREB in DC differentiation cannot be excluded.
Red recombinase expression plasmid is constructed for one-step inactivation of gene encoding pyruvate formate lyase, fumarate reductase, and LacI transcriptional repressor, respectively [14].
Klemm, "Differential temperature modulation by H-NS of the fimB and fimE recombinase genes which control the orientation of the type 1 fimbrial phase switch," FEMS Microbiology Letters, vol.
It includes a fragment (named R4') inserted into the umuC gene, which is characterized by a phage integrase (ORF38) and a phage integrase family site-specific recombinase (ORF37) and encodes 9 genes from different origins with various functions.
Overexpression of RAD51, a recombinase involved in DNA repair by homologous recombination (HR), is associated with a more aggressive cancer phenotype and treatment resistance in a variety of tumors, including ovarian, prostate, colorectal cancer, and malignant gliomas [6, 7].
Multicopy transgenes are not suitable for conditional knockout; even if transgenes are floxed (loxP sequence from bacteriophage P1 is inserted and can be recombined between two loxP sites by Cre recombinase from bacteriophage P1), only some of the copies are removed by recombinases, resulting in the failure of knockout.
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