recombinant vaccine

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recombinant vaccine

a suspension of attenuated viruses or killed microorganisms developed through recombinant DNA techniques.


a suspension of attenuated or killed microorganisms (viruses, bacteria or rickettsiae), administered for prevention, amelioration or treatment of infectious diseases.

anti-idiotype vaccine
antibody made to antigenic determinants located in the variable domains of immunoglobulin molecules. Proposed as a means of regulating antibody responses and also as a substitute antigen for vaccination.
vaccine-associated sarcoma
see sarcoma.
attenuated vaccine
a vaccine prepared from live microorganisms that have lost their virulence but retained their ability to induce protective immunity. Attenuated microorganisms including particularly bacteria and viruses may be found naturally or they may be produced in the laboratory, for example by adaptation to a new medium or cell culture or they may be produced by recombinant DNA technology.
autogenous vaccine
a vaccine prepared from cultures of material derived from a lesion of the animal to be vaccinated, e.g. wart vaccine.
bacterial vaccine
a preparation of attenuated or killed bacteria, used to immunize against organisms injected, or sometimes for pyrogenetic effects in treatment of certain noninfectious diseases.
biosynthetic vaccine
a formulation containing a protective, noninfectious, immunogenic subunit produced in or by a biological system.
caprinized vaccine
a vaccine, usually a virus, attenuated by serial passage through goats, e.g. caprinized rinderpest vaccine. In highly susceptible cattle this vaccine may cause significant reactions and lapinized vaccines are preferred.
core vaccine
one that should always be included in the basic immunization program for the species.
dead vaccine
inactivated vaccine; one with organisms that have been killed.
DNA vaccine
DNA sequences that code for immunogenic proteins located in appropriately constructed plasmids which include strong promoters, which when injected into an animal are taken up by cells and the immunogenic proteins are expressed and elicit an immune response. No vaccines of this type are licensed and concerns about safety have not been resolved.
heterotypic vaccine
one developed from a virus that is antigenically distinct but related to that causing the disease for which the animal is being immunized, e.g. measles vaccine used to protect dogs from canine distemper.
homotypic vaccine
one developed from the same virus as that causing the disease the animal is being immunized against.
human diploid cell vaccine
an inactivated rabies vaccine made from rabies virus grown on human embryo lung fibroblast cells.
inactivated vaccine
see dead vaccine (above).
killed virus (KV) vaccine
see dead vaccine (above).
live vaccine
a vaccine prepared from live, usually attenuated, microorganisms.
vaccine lymph
material containing vaccinia virus collected from vaccinial vesicles of inoculated calves; used for active immunization against smallpox.
mixed vaccine
see mixed bacterial vaccine.
modified live virus (MLV) vaccine
see attenuated vaccine (above).
polyvalent vaccine
one prepared from more than one strain or species of microorganisms.
recombinant vaccine
one created by recombinant DNA technology.
subunit vaccine
one containing only specific antigenic proteins of the infectious agent.
synthetic peptide vaccine
using synthetic short peptides which correspond with major epitopes of viral proteins to elicit a protective antibody response.
virus-vectored vaccine
use of viruses as vectors to carry selected genes from another virus for immunization.
References in periodicals archive ?
Sheep vaccinated with this recombinant vaccine construct produced neutralizing antibodies response to VP7 and on challenge with a heterotypic strain of BTV-3, six of eight animals survived the infection, demonstrating the first report on cross-serotype protection among BTV serotypes (23).
All animals immunized with recombinant vaccine (mecA) were able to produce specific antibodies anti-mecA and the highest antibody titers were observed after the third immunization (second booster).
The StabyExpress system improves the efficiency of protein production and offers the potential of increased protein yield in the manufacture of recombinant vaccines, without the use of antibiotics, whilst reducing the environmental impact.
Scientists have completed the first human clinical trial of a recombinant vaccine for the deadly toxin ricin--a potential bioterror threat--and the results indicate it is safe and effective in eliciting ricin-neutralizing antibodies, report researchers from the University of Texas Southwestern Medical Center, Dallas.
DOR has licensed international rights to a recombinant vaccine antigen from the University of Texas Southwestern Medical Center at Dallas.
Those receiving the recombinant vaccine got a booster at five years of age; those receiving the plasma-derived vaccine got a booster at nine years of age.
At the same time, work is proceeding on a recombinant vaccine in which viral DNA is piggybacked onto user-friendly bacteria.
The medical achievements included Tubular Centrifuges, Recombinant Vaccine (for human and animals) and Ultraviolet Radiation (UV) Monitoring System.

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