The significant difference in cellular uptake of [[sup.131]I]GNR-PEG-cRGD by B16F10 and MCF-7 cells confirmed receptor-specific internalization of the probes, suggesting that the probes were taken up by tumor cells via receptor-mediated endocytosis
. However, [[sup.131]I]GNR-PEG-cRGD accumulation in MCF-7 cells and blocked B16F10 cells was up to about 20% because of passive uptake, which may be explained by the following three reasons.
When a transferrin protein loaded with iron encounters a transferrin receptor on the surface of a cell, it binds to it and, as a consequence, is transported into the cell in a vesicle by receptor-mediated endocytosis
. The pH of the vesicle is reduced by hydrogen ion pumps ([H.sup.+]-ATPases) to about 5.5, causing transferrin to release its iron ions.
is a prerequisite for fusion and uncoating of all known Flaviviridae family members.
The folate-conjugated nanoparticles were found to be distributed within the cytoplasm, suggesting cellular internalization through receptor-mediated endocytosis
, instead of adhesion to the cell surface.
In the case of LDL, the downstream mechanisms involve modulation of p53, p21, and p16-pRb signal transduction pathways after LDL receptor-mediated endocytosis
of native LDL.
Targeted drug delivery via the transferrin receptor-mediated endocytosis
As well as its efficient receptor-mediated endocytosis
by dendritic cell, it could also be better presented on MFICI and MHCII.
Shen, "Synthetic glycopeptide substrates for receptor-mediated endocytosis
by macrophages," Proceedings of the National Academy of Sciences of the United States of America, vol.
Renal Uptake of 99mTc-Dimercaptosuccinic Acid Is Dependent on Normal Proximal Tubule Receptor-Mediated Endocytosis
. J Nucl Med.
Thus, a novel drug delivery system could maintain high brain permeability through receptor-mediated endocytosis
The tumor cell then folds its membrane in to enclose the receptor and prodrug in a bubble and bring them into the cell (receptor-mediated endocytosis
Roberts et al., "Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis
and the actin cytoskeleton," Traffic, vol.