Up until now its role as a chaperone protein for membrane receptor trafficking
The study, entitled 'The VLDL receptor regulates membrane progesterone receptor trafficking
and non-genomic signaling', has now been published in a leading international journal, the Journal of Cell Science.
Wu et al., "Non-genomic action of androgens is mediated by rapid phosphorylation and regulation of androgen receptor trafficking
," Cellular Physiology and Biochemistry, vol.
By contrast, the second process, retrieval (accessing the coded experience), is regulated by synaptic strength and glutamate receptor trafficking
at the time that the memory is accessed [58, 62, 63] and does not require protein translation or gene transcription [39, 58].
(2012) CCL2 promotes P2X4 receptor trafficking
to the cell surface of microglia.
Due to its ability to bind to numerous ligands, LRP1 associates with a chaperone termed the receptor-associated protein (RAP) which prevents premature ligand binding during receptor trafficking
from the endoplasmic reticulum (ER) to the Golgi.
In this setting, again, receptor trafficking
downstream of S1PR4 was affected.
Previous research has suggested that alterations caused by specific mutations depend on the location of the substituted amino acid in one of the critical regions for ligand binding, receptor trafficking
, and signal transmission but not on the extend of the defect (13).
The ins and outs of G protein-coupled receptor trafficking
. Trends Biochem.
To accomplish this function Sortilin is endowed with an ectodomain that binds a great variety of cargo proteins, and a cytosolic domain that recruits adaptor proteins to direct the receptor trafficking
In excitatory receptor trafficking
, insulin causes the internalization of AMPA receptors, resulting in long-term depression of excitatory synaptic transmission crucial for the storage of information in the brain [38, 39].
NMDA receptor trafficking
in synaptic plasticity and neuropsychiatric disorders.