Despite previous efforts to recapitulate
tumorigenesis with the use of mouse models and cancer cell lines, the exact mechanisms that underlie BRCA1 or BRCA2-dependent tumor development remain unclear.
He stressed the need to recapitulate
sacrifices made by India's forefathers in attaining independence, as well as the need to safeguard it.
ArunA's novel human stem cell based systems recapitulate
the human brain condition and could potentially reduce animal model use with translatable human high throughput screening in a dish.
December 5, 2013 -- Scientists have developed a new method for converting induced pluripotent stem cells (iPSCs) into nerve cells that recapitulate
features associated with aging as well as Parkinson's disease.
The BioMAP models also recapitulate
interactions between tumour cells, stromal and/or vascular tissue and recruited, infiltrating immune cells to the tumour, said Ellen Berg, scientific director and general manager of DiscoveRx's unit, BioSeek.
Because the models most often available to us today do not recapitulate
human disease, we can't fully understand the mechanisms behind many intestinal disorders, which means that the drugs and therapies we validate in animal models often fail to be effective when tested in humans," said Donald Ingber, Wyss Founding Director and lead researcher.
The company said because they are human cells, they better recapitulate
human biology and therefore are better predictors of drug candidate responses than current cell models.
She argues that Shakespeare's play frames the uneasy relationship between Christian and Jew specifically in familial terms in order to recapitulate
the vexed familial relationship between Christianity and Judaism.
Such disease-specific stem cells offer an unprecedented opportunity to recapitulate
both normal and pathologic human tissue formation in vitro, thereby enabling disease investigation and drug development.
The Duke researchers set up such a model using PC12 cells, a tumor cell line that originates from a neuronal phenotype and that can recapitulate
all the major phases of neurodevelopment thought to be targets for chlorpyrifos.
Most mesmerizing of all, though, are the small keys that spell out and recapitulate
the schemas of the drawings, deftly rejuvenating the coincidence of linguistic proposition and physical execution so prized by Conceptualism.
, the first polarized SUSANS instrument spanning Q > [10.