However, we cannot infer the geographic region where the reassortant virus
was generated, because the gene constellation of the virus originated from different locations.
This H5N5 strain is a contemporary reassortant virus
related to North American and Eurasian strains.
Compared with JS/1/11 EA-H1N1 virus, the reassortant virus
exhibited higher infectivity, virulence, and replication in C57BL/6J mice, demonstrating the need for further evaluation of HuN EA-H1N1 virus to assess the threat it poses to public health.
One case was associated with a clade 1.1.2 reassortant virus
, A/Vietnam/14012902/2014 (Global Initiative on Sharing All Influenza Data [GISAID; http://www.gisaid.org] accession nos.
However, the 6:2 reassortant virus
H10-JD346 virus showed markedly decreased replication compared with that of an H3N2 subtype virus (PR8 6:2 reassortant) in a human lung epithelial cell line (Figure 3, http://wwwnc.cdc.gov/EID/ article/21/7/14-1755-F3.htm).