(redirected from rearrangements)
Also found in: Dictionary, Thesaurus, Legal.


A restructuring, for example, in a molecule.
References in periodicals archive ?
First, the researchers tested the approach by generating cells with the gene rearrangement they wanted; they took a fusion gene that recurs in prostate cancer and put it into a cell line that usually lacks it.
Rearrangements of the NTRK1 gene occur in <5% of papillary thyroid carcinomas.
Under the company's Molecular Oncology and Cellular Tumor Marker permit, the HEME FISH-based assays was awarded approval for detection of amplifications or rearrangements of DNA in several hematologic cancers, including leukemias, lymphomas and myelomas in order to form a diagnosis and/or to evaluate prognosis or remission of disease.
In conjunction, the patients with either RET or ROS1 rearrangements appear to have unique clinical and pathologic features that may facilitate identification and enrichment strategies.
Carbocations often quickly rearrange before proceeding with a reaction and some rearrangements are slower than others.
Among the topics are Beyer-Villiger oxidation/rearrangement by organic synthesis, the quasi-Faborskii rearrangement, the vinylcyclopropane-cyclopentene rearrangement, [3,3]-sigmatropic rearrangements with heteroatom-heteroatom bonds, and Pummerer-type reactions as powerful tools in organic synthesis.
Translocations subdivided in groups regarding the number of chromosomes involved are: (i) one-way translocation with one-way transfer of a chromosomal segment to another chromosome; (ii) two-way translocation with two-way transfer of a chromosomal segment to another chromosome; and (iii) the most common group of complex chromosomal rearrangements (CCRs), with three or more chromosomes involved in the exchange.
Amplification of Ig genes rearrangements have been proposed as a appropriate method to lymphoma diagnosis (9).
Because current NIPT methods rely on the detection of deviations in the representation of a particular chromosome or subchromosomal region, genomic aberrations resulting from copy-number-neutral rearrangements, such as balanced translocations, have proven to be more challenging and have yet to be detected noninvasively from ccf DNA in pregnant plasma.
London, Nov 21 (ANI): An Indian born scientist and his team has discovered two cancer-spurring gene rearrangements that may trigger 5 to 7 percent of all breast cancers.
A companion study finds unusual chromosomal rearrangements in this deadly cancer, a characteristic that might provide insights into how the disease develops.
The method, known as PARE (Personalized Analysis of Rearranged Ends), "is based on next-generation mate-paired analysis of resected tumor DNA to identify individualized tumor-specific rearrangements," Dr.