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A restructuring, for example, in a molecule.
References in periodicals archive ?
Chromosome translocation, also known as chromosome rearrangement, is an abnormality caused by exchange of parts between non-homologous chromosomes.
The purpose of this investigation was design evaluation of an auxiliary approach to increase sensitivity of diagnosis and to apply BIOMED-2 molecular gene rearrangements assays on FFPE tissue in HL samples.
We simulated structural rearrangements in silico by connecting 2 randomly selected independent regions from the human reference genome (hg19).
We are routinely ordering molecular studies to detect BCL-2, BCL-6, and c-MYC rearrangements on any B-cell lymphoma with features intermediate between DLBCL and BL, any lymphoma with a Ki-67 proliferation index > 90%, and any DLBCL that has recurred and is refractory to therapy.
A year of clinical laboratory experience since its approval in the United States has established the value of the Vysis ALK Break Apart FISH assay as a rapid, sensitive and specific test for detecting ALK gene rearrangements in patients with NSCLC.
Although we could not definitively identify the ERG staining glands with FISH for evaluation of ERG rearrangement status, given the strongly clonal nature of the ERG rearrangements and the staining in individual tumor foci, this core may represent a collision of [ERG.
What's exciting is that these gene fusions and rearrangements can give us targets for potential therapies," said Arul Chinnaiyan, M.
The researchers analyzed these regions further to identify DNA sequences that displayed incorrect ordering, orientation, or spacing, and observed that an average of 9 rearrangements was found in each of the six samples (range, 4-17).
PGD for chromosomal abnormalities or rearrangements provides an alternative to prenatal diagnosis and termination of affected foetuses and theoretic enhancement of implantation and pregnancy rates for these couples (12).
When you have these rearrangements, one possibility is that the embryo doesn't have a gene when it needs it during development.
The inherited BRCA1 rearrangements were more frequently found in probands younger than 40 years of age (16%).
The theory of programmed organic evolution is proposed here on the strength of the natural existence of molecular tools and systems for rearranging and reorganizing chromosomes in the cell and the fact that these rearrangements can be carried out as a cell-directed (i.