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A restructuring, for example, in a molecule.
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The pooled control set comprised an informatically merged set of samples (plasma A, B, and C) that were believed to not contain the same or similar structural rearrangements as the test sample.
Looking at the genetic sequencing of 89 breast cancer cell lines and tumours, the researchers at the University of Michigan Comprehensive Cancer Centre found two distinct types of genetic rearrangements that appear to be driving this subset of breast cancers.
The researchers found that these patients often had a distinct pattern of chromosomal rearrangements called fold-back inversions, in which strings of DNA loop back upon themselves.
These rearrangements will then be a template to act as a fingerprint for that individual cancer.
The method his colleagues reported last month is more thorough, since the rearrangement is likely to occur in every cancer cell in the patient's body.
Just as important, the genomes were different from each other, with multiple distinctive patterns of rearrangement observed, supporting the view that breast cancer is not one, but several diseases.
PGD for chromosomal abnormalities or rearrangements provides an alternative to prenatal diagnosis and termination of affected foetuses and theoretic enhancement of implantation and pregnancy rates for these couples (12).
When you have these rearrangements, one possibility is that the embryo doesn't have a gene when it needs it during development.
The inherited BRCA1 rearrangements were more frequently found in probands younger than 40 years of age (16%).
55) Transposition plays an important role in chromosome rearrangements.
A FISH technique that utilizes a complete set of telomeric probes to screen for deletions or rearrangements specifically within the gene-rich subtelomeric regions of all chromosomes on a single slide.
While the sequence product of this kind of technology would lack some important information, such as information about genomic rearrangements, it would nevertheless potentially be available more rapidly and produce data of great value for certain uses in studying disease etiology and in individualized medicine.