Also found in: Dictionary, Thesaurus, Idioms, Encyclopedia, Wikipedia.


A restructuring, for example, in a molecule.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
Objective: To study the atypical BCR/ABL gene rearrangement patterns by Fluorescence in situ hybridization (FISH) in patients of CML and to determine their clinico-haematological characteristics and response to treatment.
Researchers at the Wellcome Sanger Institute and Hospital for Sick Children (SickKids) discovered large scale rearrangements in Ewing Sarcomas and other children's cancers, and showed that these can take years to form in bone or soft tissue, the journal Science reported.
In our study, we evaluated the rate of rearrangements of the genes BRCA1 and BRCA2 in 1809 patients at high risk for breast and ovarian carcinoma, as the current rearrangement rate is not known in the Turkish population.
NORDIC BUSINESS REPORT-February 15, 2018-Endomines reports on execution of bank debt rearrangement and repayment
M2 EQUITYBITES-February 15, 2018-Endomines reports on execution of bank debt rearrangement and repayment
Importantly, these tumors show frequent and specific rearrangement of the Ewing sarcoma breakpoint region 1 (EWSR1) gene located on chromosome 22 [5, 6].
ALK rearrangement is usually observed in patients with adenocarcinoma at a frequency of approximately 4%, and it is thought to be rarely expressed in squamous cell carcinoma (SCC) [1, 2].
The histone-lysine N-methyltransferase 2A enzyme (MLL1), encoded by the KMT2A gene, is an upregulator of global, hematopoietic gene transcription, and translocation rearrangement within KMT2A causes variable risk stratification in acute leukemia based on the final genetic outcome.
Free entry, bussing in students to racecourses, letting in children for nothing, big numbers on cloths, new silks in retina-damaging colours, the Champions Series that people either do not understand or do not understand the point of, jockeys standing under posts for said races, the new Champions Day at Ascot, the rearrangement of the two-year-old autumn season, the rearrangement back of the two-year-old autumn season, promoting jockeys, promoting female jockeys, concerts after racing, as much booze as you can drink during racing, fashions shows, talking about Frankel, talking about Frankel's offspring ...
So: they target the tumor cell because only it has this DNA rearrangement; then, when they apply the drug, only tumor cells are affected by it.
For B-leukemias, immunoglobulin (IG) gene rearrangement monitoring is commonly used (3,4).

Full browser ?