reaginic antibody


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ho·mo·cy·to·tro·pic an·ti·bod·y

antibody usually of the IgE class that has an affinity for tissues (notably mast cells) of the same or a closely related species and that, on combining with specific antigen, triggers the release of pharmacologic mediators of anaphylaxis from the cells to which it is attached; the tropism seems to depend on the Fc portion of the antibody molecule; in anaphylaxis in the guinea pig, the homocytotropic antibody involved is of the γG class.
Synonym(s): reagin (4) , reaginic antibody

ho·mo·cy·to·tro·pic an·ti·bod·y

(hō'mō-sī-tō-trō'pik an'ti-bod-ē)
Antibody of the IgE class that has an affinity for tissues (notably mast cells) of the same or a closely related species and that, on combining with specific antigen, triggers the release of pharmacologic mediators of anaphylaxis from the cells to which it is attached.
Synonym(s): reaginic antibody.

reaginic antibody

An antibody, usually of the IgE class, that binds to MAST CELLS in people prone to acute ANAPHYLACTIC (Type I hypersensitivity) reactions. In association with the ANTIGEN, such as pollen grains, reaginic antibody causes release from the mast cells of HISTAMINE, LEUKOTRIENES, PLATELET ACTIVATING FACTOR and other agents responsible for the allergic reaction. Also known as reagin.