reactogenic

(rē-ak″tŏ-jen′ik) [ react(ion) + -genic]

Capable of producing a physiologic response, as a vaccine that elicits an antibody response.

reactogenicity (-jĕ-nis′ĭt-ē)

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reactogenicity

References in periodicals archive ?

Developing a less reactogenic whole-cell vaccine might be a workaround, but it hasn't been done yet.

PERTUSSIS RESURGENCE IS REAL: But possible solutions to conundrum exist

Several countries have transitioned from using mouse brain-derived vaccine to newer, less reactogenic vaccines with simpler dosing schedules, as recommended by WHO (1).

Japanese encephalitis surveillance and immunization--Asia and Western Pacific regions, 2016

Our responsibility: Do not become discouraged or lose enthusiasm for aP, but explain to parents that, because aP is less reactogenic, it produces less protection and is less durable, particularly in school-age children.

ID consult: why are there so many pertussis outbreaks despite vaccine?

Alternative approaches to developing this vaccine included attempts at attenuation of RSV, which generally resulted in vaccine candidates that were either too reactogenic or too attenuated.

Acute viral bronchiolitis: dawn of a new era for the prevention of respiratory syncytial virus infection through vaccination

Only one negative reactogenic side-effect was associated with the vector vaccine, i.

Safety of the novel influenza viral vector Brucella abortus vaccine in pregnant heifers/Seguranca de uma nova vacina vetorial empregando o virus influenza para Brucella abortus em novilhas prenhes

However, full exploitation of OMVs as vaccines is prevented by: i) presence of potentially reactogenic compounds such as LPS, virulence factors, and toxins, ii) presence of several irrelevant proteins, which dilute immune responses, iii) lack of broadly applicable molecular tools to load OMVs with foreign antigens.

OMVAC: Outer Membrane Vesicles (OMVs) from Vaccinobacter : A Synthetic Biology approach for effective vaccines against infectious diseases and cancer

Because of side effects of WCV, such as high rates of fever and local reactions, and variable efficacy of WCVs, a less reactogenic acellular vaccine (ACV) was developed in the 1980s.

Rapid increase in pertactin-deficient Bordetella pertussis isolates, Australia

Waning of protective immunity after natural infection or vaccination and shifting from reactogenic Wc vaccines to safer but less effective Ac vaccines are some reasons for pertussis resurgence (3).

Expression, purification and characterization of three overlapping immunodominant recombinant fragments from Bordetella pertussis filamentous hemagglutinin

botulinum being spore former, a dedicated facility is required; (ii) yields of toxin production are very low; (iii) the toxoiding process involves large quantities of toxin and thus dangerous; (iv) toxoid proteins are not purified thus other proteins may influence immunogenicity or reactivity of the vaccine; and (v) since the residual levels of formalin are part of the product formulation to prevent reactivation of toxin, the vaccine is reactogenic.

Botulinum toxin: bioweapon & magic drug

In this first direct comparison of an AS03B adjuvanted split virion versus whole virion non-adjuvanted H1N1 vaccine, the adjuvanted vaccine, while more reactogenic, was more immunogenic and, importantly, achieved high seroconversion rates in children aged less than 3 years.

Kids respond better to recommended swine flu vaccine

Finally, DNA vaccines are easy to prepare and are not reactogenic (22-23).

Induction of neutralization antibodies in mice by dengue-2 envelope DNA vaccines

Lepto vaccines are the most reactogenic of all the vaccines, even more so than the rabies vaccines.

Vaccinations 101: Dr. Ron Schultz shares his vast expertise in vaccines with dog owners