reactive changes

reactive changes

term in the Bethesda classification system for reporting cervical/vaginal cytologic diagnosis that refers to changes benign in nature, associated with inflammation (including typical repair), atrophy with inflammation, radiation, an intrauterine device, and other nonspecific causes.
See also: Bethesda system, AGUS, LSIL, HSIL.
Farlex Partner Medical Dictionary © Farlex 2012

re·ac·tive chang·es

(rē-ak'tiv chānj'ĕz)
Term in the Bethesda classification system for reporting cervical or vaginal cytologic diagnoses that refers to changes of a benign nature, which are associated with inflammation (including typical repair), atrophy with inflammation, radiation, an intrauterine device, and other nonspecific causes.
See also: Bethesda system, AGUS, LSIL, HSIL
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Auxiliary findings like reactive changes, infectious organisms are listed succeeding.
ASC-US diagnosis determines cellular abnormalities more prominent than those attributable to reactive changes, but that do not meet the requirements for a squamous intraepithelial lesion (SIL) (2).
(3,4) This occurs by the presence of an in situ component, fibrotic stroma, reactive changes of a biopsy site, or particular features of the tumor (eg, carcinomas with lobular features).
There were also reactive changes and mild dysplasia (lowgrade dysplasia) in the mucosal epithelium surrounding the ulcer (Figure 1, 2).
It covers sampling and preparation technique, fixation, and staining; principles of interpretation; the normal breast; the cytology of inflammatory and reactive changes; the epidemiology, histological features, and cytology of cystic, epithelial proliferative, and fibroepithelial lesions, invasive carcinoma, and other breast neoplasms; assessment of the lymph node status; and ancillary techniques.
True vision goes beyond reactive changes to meet shifting expectations.
Reactive changes due to underlying CKD and inflammation were the most frequent findings in the BM of the patients.
The most frequent finding on histopathological analysis was reactive changes (27.5%) followed by chronic granulomatous inflammation (22.5%), atypical mononuclear infiltrate (10%), aplastic anemia, hypocellular marrow and visceral leishmaniasis (7.5% each).
"Recent studies have supported the hypothesis that astrocytes have a beneficial role contributing to amyloid-beta clearance, but also that excess amyloid-beta can lead to oxidative stress and damage, and as a consequence to reduced astrocyte functionality, leading to reactive changes and decreased neuronal support, and thereby contributing to neurodegeneration."
US and cystoscopy after 3 months showed marked regression and biopsies showed nonspecific reactive changes. At removal of the JJ catheter after 7 months, the bladder looked near normal at cystoscopy.
When smear microscopy identified changes in the cells it was difficult to differentiate between reactive changes and epithelial dysplasia (ASC-US); these changes were more often in the background of the inflammatory process (Figure 1).
In addition to VIN 1 not having any progression to malignancy, it is a diagnosis that is difficult to reproduce and may, at times, reflect reactive changes or other dermatosis.

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