gemistocytic astrocyte

(redirected from reactive astrocyte)

ge·mis·to·cyt·ic as·tro·cyte

a round to oval astrocyte cell with abundant cytoplasm containing glial filaments and an eccentric nucleus; may contain two nuclei in the cell; hypertrophy of astrocytes.
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A better understanding of the molecular mechanisms controlling reactive astrocyte function is fundamental to therapeutic interventions for brain trauma.
Rudolph et al., "Astrocytes in primary cultures express serine racemase, synthesize d-serine and acquire A1 reactive astrocyte features," Biochemical Pharmacology, vol.
Moreover, nestin is found around neural stem cells and immature astrocyte glial cells during the embryonic period; after birth, however, no nestin is found around mature astrocyte glial cells, although it reappears around reactive astrocyte glial cells.
For comparison, distal reactive astrocyte 1 mm rostral to the injury epicenter without immunological demyelination possesses a hypertrophied cell body, numerous spread processes (Figure 2(d)), and thick bands of intermediate filaments within their processes (Figure 2(h)).
Histologically, there was neuropil edema and hemorrhage in the white matter scattered in several areas of the telencephalon (Figure 1C) and near the hemorrhagic areas foci of malacia, reactive astrocytes and some inflammatory cells were observed (Figure 1C).
To arrest the disease's progress, the BGU-iGEM team will use a synthetic biology system to eliminate reactive astrocytes and prolong ALS patients lives.
It has been previously reported that reactive astrocytes of the host brain direct their processes in a direction parallel to the outgrowing axons (26), consistent with that observed in the current study.
Clarke et al., "Neurotoxic reactive astrocytes are induced by activated microglia," Nature, vol.
Jarvis et al., "The nuclear receptor ROR[alpha] exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes," Proceedings of the National Academy of Sciences of the United States of America, vol.
C3 has been localized on reactive astrocytes in human AD cases [14] and they might contribute to synapse loss by releasing complement components themselves.
Genomic analysis in mice has also suggested that the reactive astrocytes induced by a systemic LPS (5mg/kg of body weight) administration exhibit a phenotype that may be detrimental [26].