This loss creates a permissive environment for CMV reactivation
which may approach a frequency of 70 percent when either the recipient or the donor is CMV seropositive.
Two patients who started adalimumab and 1 patient who started infliximab were given prophylaxis, and no reactivation
was observed during the follow-up.
The management of HBV was evaluated, including diagnostic techniques for HBV infection and liver function screening before R-chemo, monitoring of viral replication during and after R-chemo, use of antiviral prophylaxis, and HBV reactivation
. HBV reactivation
was defined according to the consensus definition of the Chinese Society of Hematology (Chinese Medical Association), Chinese Anti-Cancer Association, and Chinese Society of Hepatology (Chinese Medical Association). For patients with active HBV infection or inactive carriers (HBsAg positive), reactivation
was defined as detectable HBV DNA or ≥1 log[sub]10 of baseline or change in status from HBeAg negative to HBeAg positive.
This retrospective study aimed to identify the frequency of HBV reactivation
and the predictive factors in patients with resolved HBV infection who were treated with a chemotherapy regime containing rituximab for B-cell lymphoma.
Three received entecavir or tenofovir disoproxil fumarate based on confirmed HBV reactivation
with a concomitant ALT rise of at least twice the upper limit of normal.
The pathophysiology behind immunotherapy-induced reactivation
may not be parallel with conventional chemotherapies and immunosuppressant-induced reactivation
as it is a promoter of T cells which is responsible for the clearance of the virus from the host.
Importantly, a series of >60 patients diagnosed by clinical findings consistently showed detection of HHV-6 reactivation
in the vast majority of patients who satisfied the other six criteria and showed clinical manifestations consistent with those reported by Bocquet et al.
Individuals whose immune systems are not fully functional are at high risk of CMV reactivation
, potentially leading to severe illness or death.
Here, we described an 88-year-old Chinese woman who developed DRESS syndrome under combined therapy of nonsteroidal anti-inflammatory drugs (NSAIDs) and chlormezanone (CM) accompanied with cytomegalovirus reactivation
. DRESS syndrome should be highly suspected in patients with symptoms, including skin rash, fever, liver involvement, hypereosinophilia, and lymphadenopathy, especially coexisted with reactivation
of the cytomegalovirus.
The virus can be reactivated from latency following an appropriate stimulus, however, and reactivation
causes lytic virus replication [1-3].
occurs most often in patients with resolved HBV infection who are exposed to profound immunosuppression.
of CMV in the human host can arise at any time with the highest risk occurring with immunosuppression, either iatrogenic or secondary to systemic medical conditions [1-3].