During the course of skin wound healing, fibrogenic growth factors such as TGF-[beta]1 cause an increase in collagen production and epithelial migration15, thus promoting re-epithelialization
of skin wounds.16 TNF-[alpha] plays an inhibitory role on TGF[beta]1 as well as collagen gene expression17 ultimately leading to decreased epithelial and collagen regeneration.18 Previously it was observed that high dose cocoa caused the maximum decrease in TNF-[alpha] level in buccal wound of rats; hence there might have been minimal inhibition on TGF-[beta] stimulation leading to acceleration of the epithelial regeneration process in group D as compared to groups A and B.11
EyeGate's product is a cross-linked thiolated carboxymethyl hyaluronic acid, or CMHA-S, platform being developed for the acceleration of re-epithelialization
of large corneal epithelial defects in patients having undergone photorefractive keratectomy, or PRK.
(11,12) Animal studies suggest possible inhibition of neovascularization by steroids that can result in delayed wound re-epithelialization
; (13,14) however, the clinical information on the effects of short-term corticosteroid administration on the healing of differentiated tissue like tympanic membrane is limited.
generally takes about 10-12 days for most people, with a maximal improvement at approximately 3 months, Dr.
Heet al., "Controlled water vapor transmission rate promotes wound-healing via wound re-epithelialization
and contraction enhancement," Scientific Reports, vol.
In comparison with Figure 1b, which also comes from the same group but is sacrificed earlier, there is re-epithelialization
and healing depicted from the histology of this group as epithelial cells start to regrow and occupy the damaged surfaces of the gastric mucosa (Figure 1c).
Further, in the re-epithelialization
process, zinc facilitates keratinocytes migration and copper promotes the process by forming disulphide linkages between Cys residues.
If the endotracheal tube is removed at the point of minor epithelial injury, it heals by primary re-epithelialization
Bladder wound attains 100% of normal tissue strength within 14- 21days post operatively (Waldron, 2003) and 30 days are required for its complete re-epithelialization
(Xie et al., 2000).
In Endoscopic band ligation, rubber bands are used to ligate oesophageal varices with subsequent necrosis and sloughing of the varix followed by fibrosis and re-epithelialization
. This technique was first described by Stiegmann and Colleagues in 1986.
Ciclosporin in a dose of 3-10mg/kg/day has, shown similar benefits and has resulted in faster re-epithelialization
. It inactivates CD8+ T cells and inhibits the release of perforin, granzyme and granulysin in addition to blocking the proapoptotic NF-kB pathway.