rate-limiting


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rate-limiting

Of a delay at any stage in a metabolic pathway that restricts the speed of the whole process. The delay point might be an enzyme that is more easily saturated with substrate than any other.
References in periodicals archive ?
Glycogen synthase kinase (GSK3) regulates glycogen synthase, the rate-limiting enzyme in glycogen synthesis.
This lack of screens and assays is the rate-limiting factor that is slowing down the removal of endocrine disruptors from the environment," Colborn says.
As the pharmaceutical industry comes under increasing pressure to develop drugs faster and more efficiently, one of the crucial rate-limiting steps is the conversion of HTS 'hits' into lead compounds for preclinical evaluation.

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