rate-limiting


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rate-limiting

Of a delay at any stage in a metabolic pathway that restricts the speed of the whole process. The delay point might be an enzyme that is more easily saturated with substrate than any other.
References in periodicals archive ?
The enzyme 1-deoxy-D-xylulose-5-phosphate synthase (DXS) catalyses the first and rate-limiting step of the MEP pathway and it is also involved in microbial vitamin B1 and vitamin B6 biosynthesis, making it an interesting target in microbes.
Kaplan also noted that Lipocine is working to resolve the four issues detailed in the CRL received in May 2018 and he expects results from the "rate-limiting" AMB BP study in late Q1.
It is an antigen-binding fragment of a humanised, monoclonal antibody directed against complement factor D, which is a rate-limiting enzyme involved in the activation of the alternative complement pathway, a component of the immune system.
Comment: Biotin is a cofactor for acetyl-CoA carboxylase, a potentially rate-limiting enzyme in myelin synthesis.
A10 Networks this week announced its Thunder TPS Release 3.1, which includes a fully programmable policy engine via the regex or enhanced aFleX commands, extends new advanced DDoS mitigation capabilities to block additional attacks such as the recent POODLE attack, and provides advanced rate-limiting for granular Layer 4-7 control to enable incident mitigation.
According to the study, the effects of glutathione supplementation on the levels of the glutathione precursor cysteine in plasma and the activity of the rate-limiting glutathione biosynthetic enzyme GCL in erythrocytes were examined after the six-month study period.
"The rate-limiting step with the current set-up is moving elderly patients in and out of a single room as this limits the number of injections we can give to around 10 per session where, potentially, we could progress to 40 per session."
Mice lacking the gene encoding brain tryptophan hydroxylase 2 (Tph2-/-), the initial and rate-limiting enzyme in the synthesis of serotonin, were tested in numerous behavioral assays that are well known for their utility in modeling human neuropsychiatric diseases.
CSIRO co-author, Dr Richard Matear said the rate-limiting step in the anthropogenic carbon uptake by the ocean is the physical transport from the surface into the ocean interior.
One of the rate-limiting steps in such studies has been library preparation and target enrichment.
This study and subsequent work (Moolgavkar and Knudson, 1981; Friends et al., 1986; Vogelstein and Kinzler, 1998) led to Knudson's two-hit hypothesis, which proposes that two hits in the Rb gene are the rate-limiting steps of retinoblastoma.
What follows are certain considerations that could be used to determine the rate-limiting factor responsible for low bioavailability:

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