RAB7A

(redirected from ras-related protein Rab-7a)

RAB7A

A gene on chromosome 3q21.3 that encodes a member of the Rab subfamily of Ras-related small GTPases, which regulates vesicle traffic in the late endosomes, as well as from late endosomes to lysosomes.

Molecular pathology
RAB7A is linked to cellular vacuolisation by the VacA cytotoxin of Helicobacter pylori; RAB7A mutations have been linked to some forms of Charcot-Marie-Tooth disease.
References in periodicals archive ?
In the protein list, we observed that when [Fe.sub.3] [O.sub.4] NPs were treated, ras-related proteins were expressed including ras-related protein Rab-7L1 (RAB7L_RAT, 3.2-folds), ras-related protein Rab-1A (RAB1A_RAT, 2.3-folds), ras-related protein Rab-2A (RAB2A_RAT, 1.6-folds), ras-related C3 botulinum toxin substrate 1 (RAC1_RAT, 1.2-folds), ras-related protein Rap-1A (RAP1A_RAT), and ras-related protein Rab-7a (RAB7A_RAT).