ras proto-oncogenes

Genes in humans and many other animals that influence cell differentiation. Mutations of ras genes may contribute to one third of all cases of cancer.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

References in periodicals archive ?

Neurofibromin is a tumor suppressor that suppresses products of ras proto-oncogenes. When it is absent, tumor progression may occur.

Neurofibromatosis type I

The RAS proto-oncogenes (ERAS, KRAS, and NRAS) encode HRAS, KRAS 4A, KRAS 4B, and NRAS, 4 distinct but closely related and highly homologous proteins.

SP174, NRAS Q61R Mutant-Specific Antibody, Cross-Reacts With KRAS Q61R Mutant Protein in Colorectal Carcinoma

The conversion of normal RAS proto-oncogenes, specifically K-RAS, to activated oncogenes is usually accomplished by point mutations involving the 12th and occasionally the 13th and 61st codons on chromosome 12.

Prevalence of K-Ras codons 12 and 13 mutations in locally advanced head and neck squamous cell carcinoma and impact on clinical outcomes

Simple and sensitive detection of mutations in the ras proto-oncogenes using PNA-mediated PCR clamping.

Biochip for K-ras mutation screening in ovarian cancer

Activating mutations in the ras proto-oncogenes are among the most commonly found alterations in cutaneous melanoma, the most fatal of skin cancers.

Pyrosequencing as an alternative to single-strand conformation polymorphism analysis for detection of N-ras mutations in human melanoma metastases

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