Researchers at the University of Illinois have been able to study precisely how Ras proteins interact with cell membrane surfaces.
Ras proteins have long been the focus of cancer research because of their role as 'on/off switch' signaling pathways that control cell division and failure to die like normal, healthy cells do.
As effectors of Ras proteins have RBD domain, through which interact with Ras protein.
In vitro were positive function of Ras proteins in the initiation of cell death .
2, ras proteins
were detected at high level after addition of Dex, which was used as an inducer of mutated human N-ras oncogene.
Decades of research have proven unsuccessful in developing a drug that can target the mutant Ras proteins
found in cancer, yet the potential remains huge so huge that the National Cancer Institute (NCI) last year announced a $10 million effort, dubbed the RAS Program, aimed at developing new ideas for targeting the protein.
Inhibiting this enzyme causes a reduction in the endogenous production of mevalonate, which in turn triggers a series of reactions resulting in decreased biologic activity of Ras proteins
and other oncogenes.
In her dissertation, Anna-Karin Sjogren studied how mutations (activation) of RAS proteins
contribute to the formation of many forms of tumors, such as cancer of the large intestine, lungs, blood and pancreas.
Mutant Ras proteins
appear in many cancers, which is why the inhibitors have stirred so much excitement (SN: 5/3/97, p.
To date it has proven impossible to target the RAS proteins
directly and it is unclear whether combined targeting of downstream pathways that RAS controls will prove effective.
Other Biotherapy including treatments such as treatments such as; antisense oligonucleotides, apoptosis, or programmed cell death, protein and polypeptide growth factors, methylation, p53 tumor suppressor proteins, ras proteins
, regulatory enzymes and other therapies.
The frequent detection of mutant ras proteins
in pancreatic and other cancers provides strong support for their role as potential drug targets.