Gusterson, "Low incidence of ras oncogene
activation in human squamous cell carcinomas," British Journal of Cancer, vol.
Brown, a cholesterol researcher at the university of Texas Southwestern Medical Center in Dallas, is to determine whether the link between cholesterol synthesis and the ras oncogene
is "a mere evolutionary fact without deeper significance" or nature's way of activating oncogenes.
Notably, moderately increased SOD3 levels stimulate cell proliferation, mimicking the function of the RAS oncogene
in primary cultures and causing mitogenic burst followed by growth arrest-related senescence, immortalization of primary cells, and even transformation of the cells together with additional changes in cellular signaling [63, 85-87].
 Human genes: PHACTR1, phosphatase and actin regulator 1; HNF1A, HNF1 homeobox A; PCSK9, proprotein convertase subtilisin/kexin type 9; SORT1, sortilin 1; SLC22A3, solute carrier family 22 (extraneuronal monoamine transporter), member 3; LPAL2, lipoprotein, Lp(a)-like 2, pseudogene; LPA, lipoprotein, Lp(a); MRAS, muscle RAS oncogene
homolog; KCNE2, potassium voltage-gated channel, Isk-related family, member 2.
The RAS oncogene
induces genomic instability in thyroid PCCL3 cells via the MAPK pathway.
In colonic adenocarcinoma, the transformation from an adenomatous (dysplastic) change to carcinoma is associated with several well-characterized molecular events, including the mutation in the ras oncogene
and in the tumor suppressor gene p53.
Mutations in the ras oncogene
are frequent in malignant pancreatic disease (10, 25,26) and variable in cholangiocarcinoma (3, 27-29).
Identification of ras oncogene
mutations in the stool of patients with curable colorectal tumors.
Clinical significance of ras oncogene
activation in human lung cancer.
Barbacid, "RAS oncogenes
: the first 30 years," Nature Reviews Cancer, vol.
Hamilton et al., "Inhibiting ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes
," Cancer Research, vol.
Bos, "ras Oncogenes
in human cancer: a review," Cancer Research, vol.