Kamata, "The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene
transformation," Cancer Research, vol.
26,27] Clinical studies reveal a low incidence of ras oncogenes
in American men with prostate cancer,[30-34] whereas a Japanese study reported the presence of ras oncogenes
in 25% of Japanese men diagnosed with prostate cancer.
Brown, a cholesterol researcher at the university of Texas Southwestern Medical Center in Dallas, is to determine whether the link between cholesterol synthesis and the ras oncogene
is "a mere evolutionary fact without deeper significance" or nature's way of activating oncogenes.
Selective activation of ras oncogenes
in follicular and undifferentiated thyroid carcinomas.
Mutations in the ras oncogene
are frequent in malignant pancreatic disease (10, 25,26) and variable in cholangiocarcinoma (3, 27-29).
Identification of ras oncogene
mutations in the stool of patients with curable colorectal tumors.
Arglabin inhibits the enzyme Farnesyl Transferase (FTase), an enzyme critical to the function of the Ras oncogene
GRB2 represents a molecular bridge between receptor tyrosine kinases (RTKs) and the intracellular ras oncogene
In addition, Genentech has a broad and intensive effort in preclinical cancer research, including: anti-VEGF, which may inhibit blood vessel growth in tumors; the Ras oncogene
, which may have the potential to stop uncontrolled cell division in certain cancers, such as pancreatic cancer; and thrombopoietin (TPO), which may be useful in treating the platelet destruction caused by irradiation and chemotherapy.
Clinical significance of ras oncogene
activation in human lung cancer.
Hypomethylation of ras oncogenes
in primary human cancers.
Bos JL (1989) Ras oncogenes
in human cancer: a review.