ras gene

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Related to ras gene: p53, RB gene, Proto oncogene

ras gene

(răs)

Any of several oncogenes that code for Ras proteins.

References in periodicals archive ?

Knowles, "FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma," Oncogene, vol.

Molecular biomarkers in bladder cancer: novel potential indicators of prognosis and treatment outcomes

Mutations in ras gene result in oncogenic activation and pathogenesis of various cancer including lung pancreatic and colorectal carcinoma and OSCC.

Dynamic of Kirsten ras and isoforms of protein kinasis in the progression of oral potentially malignant to malignant lesions

1 NATURE CELL BIOLOGY, Lee's group shows that HSV-1 replicates unusually quickly in cells that have a hyperactive Ras gene.

Herpes virus homes in on cancer target

Ras gene family (including H- K- and N-RAS) has been implicated in upwards of 30% of all human cancers; however mutation frequencies within OSCCs are varied (5-50%) and appear to be dependent on the specific RAS gene and interestingly geographic loca- tion of the population studied.

Role of protein kinases and Kirsten ras pathways in oral squamous cell carcinoma and poorly differentiated oral squamous cell carcinoma in Punjab (Pakistan) population

The researchers relied on a line of mice genetically engineered to carry a mutant Ras gene.

Diverse strategies to vanquish cancer: researchers take aim at malignancy

The best characterized tumorigenic molecular changes in FTC are activating point mutations in genes of the protooncogene family comprising HRAS [5] (v-Ha-ras Harvey rat sarcoma viral oncogene homolog), KRAS (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog), and NRAS [neuroblastoma RAS viral (v-ras) oncogene homolog] and in the PAX8/PPARG (paired box 8/peroxisome proliferator-activated receptor gamma) fusion oncogene rearrangement (3); however, RAS gene mutations (a) occur only in 10%-25% of FTC cases, (b) are also seen in papillary thyroid carcinoma, and (c) occur equally often in FA and FTC (3-5).

Evaluation of the PAX8/PPARG translocation in follicular thyroid cancer with a 4-color reverse-transcription PCR assay and automated high-resolution fragment analysis

Bert Vogelstein of Johns Hopkins Medical Institutions in Baltimore is working on a way to detect an altered version of the ras gene, which is shed in the feces of people with colorectal cancer.

Colorectal cancer: to screen or not to screen?

Prevalence of ras gene mutations in human colorectal cancers.

Mutant-enriched PCR and allele-specific hybridization reaction to detect K-ras mutations in stool DNA: high prevalence in a large sample of older adults

For example, the ras gene, when activated, may help cause colon and rectal cancer (see sidebar).

Renegade tumors

7] Previous studies have also shown that the Ras gene product showed differences of expression in verrucous carcinoma versus squamous cell carcinoma.

Differential Expression of ras Signal Transduction Mediators in Verrucous and Squamous Cell Carcinomas of the Upper Aerodigestive Tract

Whereas the RB gene speeds cancer's progress when shut off, the ras gene causes trouble when a mutation turns it on.

Genetic clues to colorectal tumors

The three members of the ras gene family, H-ras, K-ras, and N-ras, are among the most common oncogenes associated with human neoplasms (2).