ras gene


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Related to ras gene: p53, RB gene, Proto oncogene

ras gene

(răs)
n.
Any of several oncogenes that code for Ras proteins.
References in periodicals archive ?
Knowles, "FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma," Oncogene, vol.
Mutations in ras gene result in oncogenic activation and pathogenesis of various cancer including lung pancreatic and colorectal carcinoma and OSCC.
1 NATURE CELL BIOLOGY, Lee's group shows that HSV-1 replicates unusually quickly in cells that have a hyperactive Ras gene.
Ras gene family (including H- K- and N-RAS) has been implicated in upwards of 30% of all human cancers; however mutation frequencies within OSCCs are varied (5-50%) and appear to be dependent on the specific RAS gene and interestingly geographic loca- tion of the population studied.
The researchers relied on a line of mice genetically engineered to carry a mutant Ras gene.
The best characterized tumorigenic molecular changes in FTC are activating point mutations in genes of the protooncogene family comprising HRAS [5] (v-Ha-ras Harvey rat sarcoma viral oncogene homolog), KRAS (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog), and NRAS [neuroblastoma RAS viral (v-ras) oncogene homolog] and in the PAX8/PPARG (paired box 8/peroxisome proliferator-activated receptor gamma) fusion oncogene rearrangement (3); however, RAS gene mutations (a) occur only in 10%-25% of FTC cases, (b) are also seen in papillary thyroid carcinoma, and (c) occur equally often in FA and FTC (3-5).
Bert Vogelstein of Johns Hopkins Medical Institutions in Baltimore is working on a way to detect an altered version of the ras gene, which is shed in the feces of people with colorectal cancer.
For example, the ras gene, when activated, may help cause colon and rectal cancer (see sidebar).
7] Previous studies have also shown that the Ras gene product showed differences of expression in verrucous carcinoma versus squamous cell carcinoma.
Whereas the RB gene speeds cancer's progress when shut off, the ras gene causes trouble when a mutation turns it on.
The three members of the ras gene family, H-ras, K-ras, and N-ras, are among the most common oncogenes associated with human neoplasms (2).