raphe nuclei


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ra·phe nu·cle·i

[TA]
collective term denoting a variety of nerve cell groups in and along the median plane of the medulla oblongata [nucleus raphes obscurus [TA] (obscure raphe nucleus [TA]), nucleus raphes pallidus [TA] (pallidal raphe nucleus [TA]), and caudal portions of the nucleus raphes magnus [TA] (magnus raphe nucleus [TA])]; of the pons [rostral portions of the nucleus raphes magnus [TA] (magnus raphe nucleus [TA]), nucleus raphes pontis [TA] (pontine raphe nucleus [TA]), nucleus raphes medianus [TA] (median raphe nucleus [TA] or superior central nucleus [TAalt]), and caudal portions of the nucleus raphes posterior [TA] (posterior raphe nucleus [TA]) or dorsal raphe nucleus [TAalt])]; and of the mesencephalon [rostral portions of the nucleus raphe posterior [TA] (posterior raphe nucleus [TA]), nucleus linearis inferioris [TA] (inferior linear nucleus [TA]), nucleus linearis intermedius [TA] (intermediate linear nucleus [TA]), and nucleus linearis superior [TA] (superior linear nucleus [TA])]. These nuclei include neurons characterized by their containing the indolamine transmitter agent serotonin; their serotonin-carrying axons extend rostrally to the hypothalamus, septum, hippocampus, and cingulate gyrus and include projections to brainstem, cerebellum, and spinal cord.
Synonym(s): nuclei raphes [TA]

ra·phe nu·cle·i

(rā'fē nū'klē-ī) [TA]
Collective term denoting a variety of unpaired nerve cell groups in and along the median plane of the mesencephalic and rhombencephalic tegmentum: the nucleus centralis tegmenti superior, nucleus raphes dorsalis, nucleus raphes pontis, nucleus raphes magnus, nucleus raphes pallidus, and nucleus raphes obscurus. These nuclei include neurons characterized by their containing the neurotransmitter serotonin; their serotonin-carrying axons extend rostrally to the hypothalamus, septum, hippocampus, and cingulate gyrus and include projections to the brainstem, cerebellum, and spinal cord.
References in periodicals archive ?
Wheel running alters serotonin (5-HT) transporter, 5-HT1A, 5-HT1B, and alpha 1b-adrenergic receptor mRNA in the rat raphe nuclei. Biol Psychiatry 2005; 57: 559-568, doi: 10.1016/j.biopsych.2004.11.025.
It has been reported that chronic administration of 5-HT1A agonist induced desensitization of presynaptic 5HT1A receptors in the raphe nuclei and thereby enhanced the 5-HT release [25].
Serotonin-related enhancement of recovery of hind limb motor functions in spinal rats after grafting of embryonic raphe nuclei. J Neurotrauma.
"Virtually every brain structure receives innervation from the locus coeruleus and the raphe nuclei," said Dr Blier.
A second extrathalamic cortical modulatory system within the brainstem is the raphe nuclei, located in the pons and the medulla.
Previous studies have also suggested that the LHb has a close functional connection with several structures implicated in sleep homeostasis, including the preoptic hypothalamus, the raphe nuclei, and the pineal gland [27-29].
It should also be noted that some raphe nuclei, which are mainly serotonergic, play a role in the central control of respiration in mammals (4,5).
Raphe nuclei: A moderate-sized group of nuclei found in the brainstem that releases the neurotransmitter serotonin to the rest of the brain.
For example, the dorsal raphe nuclei and the medial raphe nuclei in the brainstem play a role in rapid eye movement (REM) sleep.