The company holds the exclusive license to eRapa, an improved, targeted formulation of rapamycin
originally developed at UT Health San Antonio that is being investigated to prevent cancer and other age-related medical conditions.
Researchers showed that rapamycin
worked by activating a protein quality-control pathwaythe autophagy pathwayin cells.
"The biological aging process is very similar in dogs and people," says University of Washington researcher Matt Kaeberlein, who is spearheading the rapamycin
The enzyme mammalian (or mechanistic) target of rapamycin
(mTOR) plays a key role in the control of crucial cell processes; it regulates growth and keeps it in a state of equilibrium.
The phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin
(PI3K-Akt-mTOR) signaling pathway is one of the bridges that link intracellular and extracellular signal transduction and cell response.
Mary Kay Koenig, M.D., from The University of Texas Health Science Center at Houston, and colleagues examined the efficacy and safety of topical rapamycin
for TSC-related facial angiofibromas in a study involving 179 patients.
Added to patient-derived cells in culture, rapamycin
enabled the development of more Purkinje precursor cells, improved the functioning of their synapses and increased their tendency to fire.
inhibits mTORC1 by binding the 12 kDa intracellular FK506-binding protein (FKBP12) that in turn directly interacts with mTORC1 but not with mTORC2 .
I don't know if, 5 years from now, we'll all be taking low-dose rapamycin
as an antiaging drug, but we might, especially if someone figures out the ideal dose," he said at the Hawaii Dermatology Seminar provided by Global Academy for Medical Education/Skin Disease Research Foundation.
In this study, fibroblasts from MADB patients exhibited marked nuclear abnormalities and reduced proliferation that improved upon treatment with rapamycin
and dimethylsulfoxide but not with other agents, including farnesyl transferase inhibitors.
A compound called rapamycin
may actually be able to postpone aging and death, according to the (https://www.technologyreview.com/s/603997/is-this-the-anti-aging-pill-weve-all-been-waiting-for/?set=603998) MIT Technology Review .
Bafilomycin A1, rapamycin
, and FlowCellect[TM] Autophagy LC3 Antibody-based Assay kits (FITC) were purchased from Merck Millipore, Billerica, MA.