randomised controlled trial

randomised controlled trial

A trial in which participants are assigned by chance to receive either an experimental or control treatment. When randomisation is done properly, the effect of a treatment(s) can be studied in groups of people who are:
(1) the same at the outset, and
(2) treated the same way, except for the intervention(s) being studied. Any differences seen in the groups at the end can be attributed to the difference in treatment alone, and not to bias or chance.
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References in periodicals archive ?
Randomised controlled trial of laparoscopic versus open mesh repair for inguinal hernia: outcome and cost.
COMPARISON OF LICHTENSTEIN TO TOTAL EXTRAPERITONEAL HERNIA REPAIR IN TERMS OF CLINICAL AND COST EFFECTIVENESS
In addition, the authors' conclusions regarding enteral feeding, although attractive on a physiological basis and perhaps correct, remain unproven in the absence of high-quality, level one, randomised controlled trial evidence.
Controversies in stress ulcer bleeding prophylaxis arise from differences in the quality of the evidence
Reducing SFA consumption is recommended to reduce CHD, but there is little strong randomised controlled trial (RCT) evidence of CHD events and few guidelines for specific SFA substitutes.
Replacing saturated with polyunsaturated fat to cut heart disease risk
Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial.
Does metoprolol prevent adverse outcomes for high-risk patients undergoing noncardiac surgery?
Terblanche and colleagues investigated the use of adjunctive corticosteroid treatment of clinical PCP in infants in a randomised controlled trial.
Corticosteroids in Pneumocystis jiroveci pneumonia in infants
A new randomised controlled trial of the effectiveness of an intensive exercise program immediately after hospital has recently been published (Bulthuis 2007), and new studies examining the cost effectiveness of such programs should be done.
Short-term beneficial effects of physiotherapy exercise after knee arthroplasty for osteoarthritis
Partner notification of chlamydia infection in primary care: randomised controlled trial and analysis of resource use.
Partner notification in chlamydia infection in primary care settings in England
Effect of handwashing on child health: a randomised controlled trial.
Saving lives through global safe water
Effectiveness of ototopical antibiotics for chronic suppurative otitis media in Aboriginal children: A community-based, multicentre, double-blind randomised controlled trial.
Treatment of otologic disease in Australian Aboriginal children
Randomised controlled trial of fecal occult blood screening for colorectal cancer.
New AGA guidelines are based on trials using SKD's Hemoccult II tests exclusively
Effectiveness of policy to provide breastfeeding groups (BIG) for pregnant and breastfeeding mothers in primary care: cluster randomised controlled trial.
Implementation key for breastfeeding guidance
Helicobacter pylori test and treat versus proton pump inhibitor in initial management of dyspepsia in primary care: multicentre randomised controlled trial (MRC-CUBE trial).
Dyspepsia: test and treat for H pylori or start PPIs?

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