randomised controlled trial

randomised controlled trial

A trial in which participants are assigned by chance to receive either an experimental or control treatment. When randomisation is done properly, the effect of a treatment(s) can be studied in groups of people who are:
(1) the same at the outset, and
(2) treated the same way, except for the intervention(s) being studied. Any differences seen in the groups at the end can be attributed to the difference in treatment alone, and not to bias or chance.
References in periodicals archive ?
In addition, the authors' conclusions regarding enteral feeding, although attractive on a physiological basis and perhaps correct, remain unproven in the absence of high-quality, level one, randomised controlled trial evidence.
Reducing SFA consumption is recommended to reduce CHD, but there is little strong randomised controlled trial (RCT) evidence of CHD events and few guidelines for specific SFA substitutes.
Analyses from the extended follow-up of participants in a male circumcision randomised controlled trial conducted in Kisumu, Kenya, indicate that the protective effect of male circumcision was sustained, and possibly strengthened, for at least 42 months.
A new randomised controlled trial of the effectiveness of an intensive exercise program immediately after hospital has recently been published (Bulthuis 2007), and new studies examining the cost effectiveness of such programs should be done.
Effect of handwashing on child health: a randomised controlled trial.
Effectiveness of ototopical antibiotics for chronic suppurative otitis media in Aboriginal children: A community-based, multicentre, double-blind randomised controlled trial.
Randomised controlled trial of labouring in water compared with standard augmentation for management of dystocia in first stage of labour, British Medical Journal, 2004, 328(7435):314-319.
Cluett E et al (2004) Randomised controlled trial of labouring in water compared with standard of augmentation for management of dystocia in first stage of labour.
Randomised controlled trial of fecal occult blood screening for colorectal cancer.
Effectiveness of policy to provide breastfeeding groups (BIG) for pregnant and breastfeeding mothers in primary care: cluster randomised controlled trial.
Terblanche and colleagues investigated the use of adjunctive corticosteroid treatment of clinical PCP in infants in a randomised controlled trial.
For example, there were consistent findings in multiple low quality trials or one high quality randomised controlled trial (some positive indications that therapeutic exercise may be effective).