raltitrexed


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raltitrexed

A folate analogue drug used in the palliative treatment of advanced cancer of the colon or rectum. A brand name is Tomudex.
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Contract awarded for supply of raltitrexed 2mg vials
A rapid and systematic review of the evidence for the clinical effectiveness and cost-effectiveness of irinotekan, oxalyplatin and raltitrexed for the treatment of advanced colorectal cancer, Health Technology Assessment NHS R&D HTA Program, Health Technol Assess.
Hietschold, Open, randomized, multicenter trial of raltitrexed versus fluorouracil plus high-dose leucovorin in patients with advanced colorectal cancer.
Severe enteropathy associated with raltitrexed and oxaliplatin chemotherapy: report of two patients experiencing this rare, potentially lethal gastrointestinal adverse event.
Selected Drugs Associated With Treatment-Induced Diarrhea Older Agents Targeted Biologics New Compounds * 5-FU-based regimens Lapatinib (plus Histone deacetylase capecitabine) inhibitors (chidamide) Capecitabine Erlotinib Heat shock protein 90 inhibitor (AUY922) Irinotecan Cetuximab, Raf kinase inhibitor panitumumab (XL281) Taxanes Sorafenib, Proteasome inhibitor sunitinib (carfilzomib) Cisplatin Bortezomib Methotrexate Imatinib Raltitrexed * Reported at ASCO 2009 to have dose-limiting toxicity.