ragged red fibres

ragged red fibres

A feature of several MITOCHONDRIAL DNA disorders in which a high proportion of the muscle fibres contain structurally and functionally abnormal mitochondria. When stained and examined under the microscope these fibres appear red and ragged. The finding is commonly associated with slowly progressive weakness of the muscles of the limbs, defects of ocular movements, abnormally rapid tiredness on exertion, and a marked rise in the levels of lactic acid in the blood on exertion or even at rest.
References in periodicals archive ?
Minutes from the Human Fertilisation and Embryology Authority's (HFEA) approval committee say that the two women carry mutations in a gene that causes a rare condition known as myoclonic epilepsy with ragged red fibres, or Merrf syndrome.
Dean Norris, 28, also of Southam, suffers from myoclonic epilepsy with ragged red fibres disease, which causes him to jerk uncontrollably and is depriving him of the use of his right arm.