Radixin Upregulates MMP-7 Production via Rac1 and ERK1/2 Activation.
Among the ERM proteins, radixin has been known as an important player in cell-cell and cell-matrix contacts, as well as in the reorganization of actin cytoskeleton .
Clinical studies have observed the expression pattern of radixin in different cancers.
It is reported that radixin can regulate cell migration and cell-cell adhesion through Rac1 activation in prostate cancer cells .
However, the relationship between radixin and ERK pathway remains unclear.
Here, our results proved that radixin increased the expression and secretion of MMP-7.
In summary, our present work demonstrates that radixin can promote the invasion of colon cancer cells by activating Rac1-ERK pathway and upregulating MMP-7 production.
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