radixin


Also found in: Acronyms.

radixin

(rah-diks'in),
A protein that belongs to the ERM (that is, ezrin, radixin, and moesin) group of the band 4.1 superfamily of membrane proteins; appears to function in establishing links between the cell membrane and the underlying cytoskeleton. It also has been suggested to have some function in the formation of microvilli and in the establishment of adhesion between cells and between the cell and the extracellular matrix.
References in periodicals archive ?
Radixin Upregulates MMP-7 Production via Rac1 and ERK1/2 Activation.
Among the ERM proteins, radixin has been known as an important player in cell-cell and cell-matrix contacts, as well as in the reorganization of actin cytoskeleton [13].
Clinical studies have observed the expression pattern of radixin in different cancers.
It is reported that radixin can regulate cell migration and cell-cell adhesion through Rac1 activation in prostate cancer cells [25].
However, the relationship between radixin and ERK pathway remains unclear.
Here, our results proved that radixin increased the expression and secretion of MMP-7.
In summary, our present work demonstrates that radixin can promote the invasion of colon cancer cells by activating Rac1-ERK pathway and upregulating MMP-7 production.
Jiang, "Expression of the ERM family members (ezrin, radixin and moesin) in breast cancer," Experimental and Therapeutic Medicine, vol.
Lu, "Concomitant microRNA-31 downregulation and radixin upregulation predicts advanced tumor progression and unfavorable prognosis in patients with gliomas," Journal of the Neurological Sciences, vol.
Huang et al., "MicroRNA-409 suppresses tumour cell invasion and metastasis by directly targeting radixin in gastric cancers," Oncogene, vol.
Han et al., "Human miR-31 targets radixin and inhibits migration and invasion of glioma cells," Oncology Reports, vol.