Cisplatin is the backbone of chemotherapies for many cancer types, and it is an important radiosensitizer
that is efficiently used in many squamous cancer types, such as head, neck, and cervical carcinoma.
Temozolomide is the routinely used radiosensitizer
during radiotherapy and chemotherapy cycles and has shown good results.
Rosiglitazone, as a novel radiosensitizer
, suppresses radiation-induced survival signals and DNA damage response and enhances the radiation-induced apoptosis signaling cascade .
Moreover, it was possible to show that administration of the radiosensitizer
tirapazamine prior to radiotherapy was beneficial in hypoxic, but not in normoxic, tumors.
Aggarwal, "Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer
for tumors and chemoprotector and radioprotector for normal organs," Nutrition and Cancer, vol.
Therefore, development of an effective radiosensitizer
to enhance the radiosensitivity of hepatoma cells will play an important role in the treatment of HCC.
After radiation, AuNPs would act as a radiosensitizer
and DOX would treat the tumor as a chemotherapeutic .
Rodriguez-Aguayo et al., "MiR-205 acts as a tumour radiosensitizer
by targeting ZEB1 and Ubc13," Nature Communications, vol.
Moreover, the current study reported for the first time that harmine showed the potential to be a promising radiosensitizer
Luteolin acts as a radiosensitizer
in nonsmall cell lung cancer cells by enhancing apoptotic cell death through activation of a p38/ROS/caspase cascade.
(15) Furthermore, radiotherapy has now been shown to induce thymidine phosphorylase expression, (16) and daily administration mimicking the continuous infusion of 5-FU can act as a radiosensitizer
for every fraction of radiotherapy.
Tucson, AZ, December 07, 2015 --(PR.com)-- Tucson based pharmaceutical company NuvOx Pharma announced today that it has secured orphan drug designation from the FDA for its investigational radiosensitizer
for glioblastoma multiforme.