innoxia species alkaloids and with regard to its positive radiosensitivity
response we performed an analysis of major alkaloids (atropine and scopolamine) by means of GC on both irradiated and control seeds.
Although absorbed dose describes the amount of energy absorbed in a 3-D volume, it does not take into account which organs or tissues absorbed the dose, their relative radiosensitivity
or the risk of detrimental effects to those organs.
Additionally, low Ku70 expression in tumors with this genotype may indicate less effective DSBs repair, and thus, radiosensitivity
, which could be in agreement with the experimental study showing the connection between inactivation of Ku70 protein and hypersensitivity to infrared radiation (IR) (22).
Our previous studies found that miR-21 could modulate the radiosensitivity
of cervical cancer cells through targeting LATS1 , while miR-375 could regulate the sensitivity by targeting UBE3A .
index (RSI) developed by Torres-Roca and colleagues uses a systems biology approach and fraction of cells surviving 2 Gy (SF2) to define a clinically validated molecular signature that estimates radiosensitivity
of multiple tumor types, including breast cancer .
Hu, "Coroglaucigenin enhances the radiosensitivity
of human lung cancer cells through Nrf2/ROS pathway," Oncotarget, vol.
Pandey et al., "Curcumin modulates the radiosensitivity
of colorectal cancer cells by suppressing constitutive and inducible NF-kB activity," International Journal of Radiation Oncology Biology Physics, vol.
Schem et al., "In vitro effects of imatinib mesylate on radiosensitivity
and chemosensitivity of breast cancer cells," BMC Cancer, vol.
Cui, "MicroRNA-216a enhances the radiosensitivity
of pancreatic cancer cells by inhibiting beclin-1-mediated autophagy," Oncology Reports, vol.
In addition tissue of origin has been associated with radiosensitivity
. For example, the SF2 (survival fraction of cells after 2 Gy of radiation) of melanoma and glioma cell lines has been shown to be higher (radioresistant) than lymphoma and myeloma cell lines [7-9].
Therefore, development of an effective radiosensitizer to enhance the radiosensitivity
of hepatoma cells will play an important role in the treatment of HCC.
(9) It is speculated that defects in DNA repair mechanisms seen in these patients may increase radiosensitivity
and susceptibility to carcinogenesis in the surviving cells.