It may be that radiation-induced genomic instability specifically activates the NF[kappa]B/HER2 pathway to increase cell survival or that it selects for radioresistant
stem/progenitors with a high level of background NF[kappa]B/HER2 activity, encouraging repopulation with radioresistant
bovis AF2122/97 CGL Bacteria Actinobacteria Corynebacterium glutamicum ATCC CEF Bacteria Actinobacteria Corynebacterium efficiens YS-314 SCO Bacteria Actinobacteria Streptomyces coelicolor A3(2) SMA Bacteria Actinobacteria Streptomyces avermitilis FNU Bacteria Fusobacteria Fusobacterium nucleatum ATCC 25586 LIL* Bacteria Spirochete Leptospira interrogans 56601 DRA Bacteria Radioresistant
bacteria Deinococcus radiodurans R1 HAL Archaea Euryarchaeota Halobacterium sp.
Because a woman's gametes are arrested for long periods of time at various points in their life cycle (in stark contrast to the male system in which replication is continuous), a woman's gametes are largely radioresistant
for much of their life.
6,33) Surgical therapy may be the initial therapy in radioresistant
lesions and in patients where vertebral body metastasis is the first manifestation of an occult primary tumor.
Although this type of tumor is generally considered radioresistant
, radiation therapy is often prescribed after surgical resection.
Genome Sequence of the Radioresistant
Bacterium Deinococcus radiodurans R1.
Saenger's irradiated cancer patients had radioresistant
tumors, allowing researchers to be sure that the symptoms they suffered were caused by the radiation only, not complicated by the effects of the tumor destruction.
Generally speaking, cells are significantly more radioresistant
in the late S phase,|19,20~ but also are extremely sensitive to thermal cytotoxic treatment.
These results suggest that darinaparsin has the potential to sensitize relatively radioresistant
tumors without affecting normal tissues," commented senior author, Susan J.
2-Methoxyestradiol, an endogenous estrogen metabolite, sensitizes radioresistant
MCF-7/FIR breast cancer cells through multiple mechanisms.
13 The stem spermatogonia are relatively radioresistant
and they immediately repopulate the seminiferous epithelium in mice.
The only treatment for schwannoma is wide local excision through an approach allowing adequate exposure as schwannoma are generally radioresistant